null
SMILES: Cc1ccc(O)cc1Nc1ccnc2ccc(cc12)S(C)(=O)=O
InChI Key: InChIKey=BVHZLDLRNBQWRF-UHFFFAOYSA-N
PDB links: 1 PDB ID matches this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assay | Eur J Med Chem 161: 479-492 (2019) Article DOI: 10.1016/j.ejmech.2018.10.050 BindingDB Entry DOI: 10.7270/Q2C53Q5T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization... | Bioorg Med Chem 26: 4014-4024 (2018) Article DOI: 10.1016/j.bmc.2018.06.027 BindingDB Entry DOI: 10.7270/Q29Z97K0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | 588 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assay | Eur J Med Chem 161: 479-492 (2019) Article DOI: 10.1016/j.ejmech.2018.10.050 BindingDB Entry DOI: 10.7270/Q2C53Q5T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | 588 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl... | Bioorg Med Chem 26: 4014-4024 (2018) Article DOI: 10.1016/j.bmc.2018.06.027 BindingDB Entry DOI: 10.7270/Q29Z97K0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | 589 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assay | Eur J Med Chem 161: 479-492 (2019) Article DOI: 10.1016/j.ejmech.2018.10.050 BindingDB Entry DOI: 10.7270/Q2C53Q5T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 14 (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of p38alpha (unknown origin) | J Med Chem 59: 4867-80 (2016) Article DOI: 10.1021/acs.jmedchem.6b00211 BindingDB Entry DOI: 10.7270/Q2G162SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 186 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of VEGFR2(unknown origin) | J Med Chem 59: 4867-80 (2016) Article DOI: 10.1021/acs.jmedchem.6b00211 BindingDB Entry DOI: 10.7270/Q2G162SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of RIP2K in MDP-stimulated HEK-293 cells over-expressing NOD2 assessed as IL8 secretion | J Med Chem 59: 4867-80 (2016) Article DOI: 10.1021/acs.jmedchem.6b00211 BindingDB Entry DOI: 10.7270/Q2G162SQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 177 | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization... | Bioorg Med Chem 26: 4014-4024 (2018) Article DOI: 10.1016/j.bmc.2018.06.027 BindingDB Entry DOI: 10.7270/Q29Z97K0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 775 | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl... | Bioorg Med Chem 26: 4014-4024 (2018) Article DOI: 10.1016/j.bmc.2018.06.027 BindingDB Entry DOI: 10.7270/Q29Z97K0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Inhibition of RIP2K in Pam2CSK4-stimulated HEK-293 cells over-expressing TLR2 assessed as IL8 secretion | J Med Chem 59: 4867-80 (2016) Article DOI: 10.1021/acs.jmedchem.6b00211 BindingDB Entry DOI: 10.7270/Q2G162SQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll... | J Med Chem 59: 4867-80 (2016) Article DOI: 10.1021/acs.jmedchem.6b00211 BindingDB Entry DOI: 10.7270/Q2G162SQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 775 | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assay | Eur J Med Chem 161: 479-492 (2019) Article DOI: 10.1016/j.ejmech.2018.10.050 BindingDB Entry DOI: 10.7270/Q2C53Q5T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in... | Bioorg Med Chem Lett 17: 5886-93 (2007) Article DOI: 10.1016/j.bmcl.2007.07.104 BindingDB Entry DOI: 10.7270/Q2H1309S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | Article PubMed | n/a | n/a | 177 | n/a | n/a | n/a | n/a | n/a | n/a |
Martin-Luther-University Halle-Wittenberg Curated by ChEMBL | Assay Description Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assay | Eur J Med Chem 161: 479-492 (2019) Article DOI: 10.1016/j.ejmech.2018.10.050 BindingDB Entry DOI: 10.7270/Q2C53Q5T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human)) | BDBM25198 (3-[(6-methanesulfonylquinolin-4-yl)amino]-4-methyl...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents | PDB Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline Curated by ChEMBL | Assay Description Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll... | J Med Chem 59: 4867-80 (2016) Article DOI: 10.1021/acs.jmedchem.6b00211 BindingDB Entry DOI: 10.7270/Q2G162SQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |