BDBM252727 US9458176, 124

SMILES: C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(c(C)c1)C(F)(F)F)-c1cc(C)nc(C)c1

InChI Key: InChIKey=VPLUBPIQRLYTPL-MRXNPFEDSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 252727   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM252727 (US9458176, 124) Show SMILES C[C@@H]1Cn2c(CCO1)c(nc2-c1ccc(c(C)c1)C(F)(F)F)-c1cc(C)nc(C)c1 |r| Show InChI InChI=1S/C23H24F3N3O/c1-13-9-17(5-6-19(13)23(24,25)26)22-28-21(18-10-14(2)27-15(3)11-18)20-7-8-30-16(4)12-29(20)22/h5-6,9-11,16H,7-8,12H2,1-4H3/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.5	n/a	n/a	n/a	n/a	n/a	25
Eisai R&D Management Co., Ltd. US Patent					Assay Description The frozen cell membrane fraction prepared as described above was thawed before use, and the resultant was diluted with a buffer for a binding assay ...				US Patent US9458176 (2016) BindingDB Entry DOI: 10.7270/Q2PK0F3D
					More data for this Ligand-Target Pair