BDBM25406 4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid::CHEMBL240808::Triclosan derivative, 7

SMILES: OC(=O)c1ccc(Oc2ccc(Cl)cc2Cl)c(O)c1

InChI Key: InChIKey=KUJXLYCFJYCPHN-UHFFFAOYSA-N

Data: 2 IC50  1 Kd

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 25406   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Enoyl-ACP Reductase (PfENR) (Plasmodium falciparum)	BDBM25406 (4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid | CH...) Show SMILES OC(=O)c1ccc(Oc2ccc(Cl)cc2Cl)c(O)c1 Show InChI InChI=1S/C13H8Cl2O4/c14-8-2-4-11(9(15)6-8)19-12-3-1-7(13(17)18)5-10(12)16/h1-6,16H,(H,17,18)	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.9	25
Jacobus Pharmaceutical Company					Assay Description PfENR inhibition assays were carried out on a Cary 100 Bio Spectrophotometer or POLARstar Optima by monitoring oxidation of NADH at 340 nm. The IC50 ...				J Biol Chem 282: 25436-44 (2007) Article DOI: 10.1074/jbc.M701813200 BindingDB Entry DOI: 10.7270/Q22V2DFD
					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM25406 (4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid | CH...) Show SMILES OC(=O)c1ccc(Oc2ccc(Cl)cc2Cl)c(O)c1 Show InChI InChI=1S/C13H8Cl2O4/c14-8-2-4-11(9(15)6-8)19-12-3-1-7(13(17)18)5-10(12)16/h1-6,16H,(H,17,18)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.59E+3	n/a	n/a	n/a	n/a	4.4	n/a
Institute of Sciences Curated by ChEMBL					Assay Description Inhibition of transthyretin fibril formation at pH 4.4				J Med Chem 50: 5589-99 (2007) Article DOI: 10.1021/jm0700159 BindingDB Entry DOI: 10.7270/Q2PG1RGD
					More data for this Ligand-Target Pair
Transthyretin (Homo sapiens (Human))	BDBM25406 (4-(2,4-dichlorophenoxy)-3-hydroxybenzoic acid | CH...) Show SMILES OC(=O)c1ccc(Oc2ccc(Cl)cc2Cl)c(O)c1 Show InChI InChI=1S/C13H8Cl2O4/c14-8-2-4-11(9(15)6-8)19-12-3-1-7(13(17)18)5-10(12)16/h1-6,16H,(H,17,18)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	27	n/a	n/a	n/a	4.4	n/a
Institute of Sciences Curated by ChEMBL					Assay Description Binding affinity to transthyretin at pH 4.4				J Med Chem 50: 5589-99 (2007) Article DOI: 10.1021/jm0700159 BindingDB Entry DOI: 10.7270/Q2PG1RGD
					More data for this Ligand-Target Pair