null

SMILES: CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1

InChI Key: InChIKey=XVFNSJIPVWAPNE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 254750   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254750 (US9475775, 17 | US9475775, 54 | US9597333, 54) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1 |t:9,18| Show InChI InChI=1S/C26H33N5O2/c1-3-12-31(13-4-2)26(33)21-15-19-8-9-20(16-23(19)30-24(28)17-21)25(32)29-22-7-5-6-18(14-22)10-11-27/h5-9,14-16H,3-4,10-13,17,27H2,1-2H3,(H2,28,30)(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254750 (US9475775, 17 | US9475775, 54 | US9597333, 54) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1 |t:9,18| Show InChI InChI=1S/C26H33N5O2/c1-3-12-31(13-4-2)26(33)21-15-19-8-9-20(16-23(19)30-24(28)17-21)25(32)29-22-7-5-6-18(14-22)10-11-27/h5-9,14-16H,3-4,10-13,17,27H2,1-2H3,(H2,28,30)(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254750 (US9475775, 17 | US9475775, 54 | US9597333, 54) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1 |t:9,18| Show InChI InChI=1S/C26H33N5O2/c1-3-12-31(13-4-2)26(33)21-15-19-8-9-20(16-23(19)30-24(28)17-21)25(32)29-22-7-5-6-18(14-22)10-11-27/h5-9,14-16H,3-4,10-13,17,27H2,1-2H3,(H2,28,30)(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254750 (US9475775, 17 | US9475775, 54 | US9597333, 54) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1 |t:9,18| Show InChI InChI=1S/C26H33N5O2/c1-3-12-31(13-4-2)26(33)21-15-19-8-9-20(16-23(19)30-24(28)17-21)25(32)29-22-7-5-6-18(14-22)10-11-27/h5-9,14-16H,3-4,10-13,17,27H2,1-2H3,(H2,28,30)(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254750 (US9475775, 17 | US9475775, 54 | US9597333, 54) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1 |t:9,18| Show InChI InChI=1S/C26H33N5O2/c1-3-12-31(13-4-2)26(33)21-15-19-8-9-20(16-23(19)30-24(28)17-21)25(32)29-22-7-5-6-18(14-22)10-11-27/h5-9,14-16H,3-4,10-13,17,27H2,1-2H3,(H2,28,30)(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254750 (US9475775, 17 | US9475775, 54 | US9597333, 54) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1 |t:9,18| Show InChI InChI=1S/C26H33N5O2/c1-3-12-31(13-4-2)26(33)21-15-19-8-9-20(16-23(19)30-24(28)17-21)25(32)29-22-7-5-6-18(14-22)10-11-27/h5-9,14-16H,3-4,10-13,17,27H2,1-2H3,(H2,28,30)(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254750 (US9475775, 17 | US9475775, 54 | US9597333, 54) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1 |t:9,18| Show InChI InChI=1S/C26H33N5O2/c1-3-12-31(13-4-2)26(33)21-15-19-8-9-20(16-23(19)30-24(28)17-21)25(32)29-22-7-5-6-18(14-22)10-11-27/h5-9,14-16H,3-4,10-13,17,27H2,1-2H3,(H2,28,30)(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254750 (US9475775, 17 | US9475775, 54 | US9597333, 54) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(CCN)c1 |t:9,18| Show InChI InChI=1S/C26H33N5O2/c1-3-12-31(13-4-2)26(33)21-15-19-8-9-20(16-23(19)30-24(28)17-21)25(32)29-22-7-5-6-18(14-22)10-11-27/h5-9,14-16H,3-4,10-13,17,27H2,1-2H3,(H2,28,30)(H,29,32)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair