null

SMILES: CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(C)cc1

InChI Key: InChIKey=KAWHNQIGBMNNFB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 254761   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254761 (US9475775, 28 | US9597333, 28) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(C)cc1 |t:9,18| Show InChI InChI=1S/C25H30N4O2/c1-4-12-29(13-5-2)25(31)20-14-18-8-9-19(15-22(18)28-23(26)16-20)24(30)27-21-10-6-17(3)7-11-21/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H2,26,28)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254761 (US9475775, 28 | US9597333, 28) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(C)cc1 |t:9,18| Show InChI InChI=1S/C25H30N4O2/c1-4-12-29(13-5-2)25(31)20-14-18-8-9-19(15-22(18)28-23(26)16-20)24(30)27-21-10-6-17(3)7-11-21/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H2,26,28)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254761 (US9475775, 28 | US9597333, 28) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(C)cc1 |t:9,18| Show InChI InChI=1S/C25H30N4O2/c1-4-12-29(13-5-2)25(31)20-14-18-8-9-19(15-22(18)28-23(26)16-20)24(30)27-21-10-6-17(3)7-11-21/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H2,26,28)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254761 (US9475775, 28 | US9597333, 28) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1ccc(C)cc1 |t:9,18| Show InChI InChI=1S/C25H30N4O2/c1-4-12-29(13-5-2)25(31)20-14-18-8-9-19(15-22(18)28-23(26)16-20)24(30)27-21-10-6-17(3)7-11-21/h6-11,14-15H,4-5,12-13,16H2,1-3H3,(H2,26,28)(H,27,30)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair