BDBM254777 US9475775, 44::US9475775, 79::US9597333, 44

SMILES: CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCC)c1

InChI Key: InChIKey=LTTLXAFKULCCIV-UHFFFAOYSA-N

Data: 6 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 254777   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254777 (US9475775, 44 | US9475775, 79 | US9597333, 44) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCC)c1 |t:9,18| Show InChI InChI=1S/C25H31N5O3/c1-4-9-30(10-5-2)25(32)19-11-17-7-8-18(12-22(17)29-23(26)13-19)24(31)28-20-14-21(33-6-3)16-27-15-20/h7-8,11-12,14-16H,4-6,9-10,13H2,1-3H3,(H2,26,29)(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254777 (US9475775, 44 | US9475775, 79 | US9597333, 44) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCC)c1 |t:9,18| Show InChI InChI=1S/C25H31N5O3/c1-4-9-30(10-5-2)25(32)19-11-17-7-8-18(12-22(17)29-23(26)13-19)24(31)28-20-14-21(33-6-3)16-27-15-20/h7-8,11-12,14-16H,4-6,9-10,13H2,1-3H3,(H2,26,29)(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254777 (US9475775, 44 | US9475775, 79 | US9597333, 44) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCC)c1 |t:9,18| Show InChI InChI=1S/C25H31N5O3/c1-4-9-30(10-5-2)25(32)19-11-17-7-8-18(12-22(17)29-23(26)13-19)24(31)28-20-14-21(33-6-3)16-27-15-20/h7-8,11-12,14-16H,4-6,9-10,13H2,1-3H3,(H2,26,29)(H,28,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254777 (US9475775, 44 | US9475775, 79 | US9597333, 44) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCC)c1 |t:9,18| Show InChI InChI=1S/C25H31N5O3/c1-4-9-30(10-5-2)25(32)19-11-17-7-8-18(12-22(17)29-23(26)13-19)24(31)28-20-14-21(33-6-3)16-27-15-20/h7-8,11-12,14-16H,4-6,9-10,13H2,1-3H3,(H2,26,29)(H,28,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254777 (US9475775, 44 | US9475775, 79 | US9597333, 44) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCC)c1 |t:9,18| Show InChI InChI=1S/C25H31N5O3/c1-4-9-30(10-5-2)25(32)19-11-17-7-8-18(12-22(17)29-23(26)13-19)24(31)28-20-14-21(33-6-3)16-27-15-20/h7-8,11-12,14-16H,4-6,9-10,13H2,1-3H3,(H2,26,29)(H,28,31)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254777 (US9475775, 44 | US9475775, 79 | US9597333, 44) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCC)c1 |t:9,18| Show InChI InChI=1S/C25H31N5O3/c1-4-9-30(10-5-2)25(32)19-11-17-7-8-18(12-22(17)29-23(26)13-19)24(31)28-20-14-21(33-6-3)16-27-15-20/h7-8,11-12,14-16H,4-6,9-10,13H2,1-3H3,(H2,26,29)(H,28,31)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair