BDBM254779 US9475775, 46::US9597333, 46

SMILES: CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCCCCCN)c1

InChI Key: InChIKey=OFSXCJKXCHECCW-UHFFFAOYSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 254779   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254779 (US9475775, 46 | US9597333, 46) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCCCCCN)c1 |t:9,18| Show InChI InChI=1S/C28H38N6O3/c1-3-11-34(12-4-2)28(36)22-14-20-8-9-21(15-25(20)33-26(30)16-22)27(35)32-23-17-24(19-31-18-23)37-13-7-5-6-10-29/h8-9,14-15,17-19H,3-7,10-13,16,29H2,1-2H3,(H2,30,33)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254779 (US9475775, 46 | US9597333, 46) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCCCCCN)c1 |t:9,18| Show InChI InChI=1S/C28H38N6O3/c1-3-11-34(12-4-2)28(36)22-14-20-8-9-21(15-25(20)33-26(30)16-22)27(35)32-23-17-24(19-31-18-23)37-13-7-5-6-10-29/h8-9,14-15,17-19H,3-7,10-13,16,29H2,1-2H3,(H2,30,33)(H,32,35)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254779 (US9475775, 46 | US9597333, 46) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCCCCCN)c1 |t:9,18| Show InChI InChI=1S/C28H38N6O3/c1-3-11-34(12-4-2)28(36)22-14-20-8-9-21(15-25(20)33-26(30)16-22)27(35)32-23-17-24(19-31-18-23)37-13-7-5-6-10-29/h8-9,14-15,17-19H,3-7,10-13,16,29H2,1-2H3,(H2,30,33)(H,32,35)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254779 (US9475775, 46 | US9597333, 46) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cncc(OCCCCCN)c1 |t:9,18| Show InChI InChI=1S/C28H38N6O3/c1-3-11-34(12-4-2)28(36)22-14-20-8-9-21(15-25(20)33-26(30)16-22)27(35)32-23-17-24(19-31-18-23)37-13-7-5-6-10-29/h8-9,14-15,17-19H,3-7,10-13,16,29H2,1-2H3,(H2,30,33)(H,32,35)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair