null

SMILES: CCCN(Cc1ccc(CN)cc1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1

InChI Key: InChIKey=NXLIEOISWQPZLA-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 254793   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254793 (US9475775, 60 | US9597333, 60) Show SMILES CCCN(Cc1ccc(CN)cc1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1 |t:16,25| Show InChI InChI=1S/C30H33N5O2/c1-3-13-35(19-22-9-7-21(18-31)8-10-22)30(37)25-15-23-11-12-24(16-27(23)34-28(32)17-25)29(36)33-26-6-4-5-20(2)14-26/h4-12,14-16H,3,13,17-19,31H2,1-2H3,(H2,32,34)(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254793 (US9475775, 60 | US9597333, 60) Show SMILES CCCN(Cc1ccc(CN)cc1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1 |t:16,25| Show InChI InChI=1S/C30H33N5O2/c1-3-13-35(19-22-9-7-21(18-31)8-10-22)30(37)25-15-23-11-12-24(16-27(23)34-28(32)17-25)29(36)33-26-6-4-5-20(2)14-26/h4-12,14-16H,3,13,17-19,31H2,1-2H3,(H2,32,34)(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM254793 (US9475775, 60 | US9597333, 60) Show SMILES CCCN(Cc1ccc(CN)cc1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1 |t:16,25| Show InChI InChI=1S/C30H33N5O2/c1-3-13-35(19-22-9-7-21(18-31)8-10-22)30(37)25-15-23-11-12-24(16-27(23)34-28(32)17-25)29(36)33-26-6-4-5-20(2)14-26/h4-12,14-16H,3,13,17-19,31H2,1-2H3,(H2,32,34)(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	27	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9597333 (2017) BindingDB Entry DOI: 10.7270/Q2474CXF
					More data for this Ligand-Target Pair
Toll-like receptor 7 (Homo sapiens (Human))	BDBM254793 (US9475775, 60 | US9597333, 60) Show SMILES CCCN(Cc1ccc(CN)cc1)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C(=O)Nc1cccc(C)c1 |t:16,25| Show InChI InChI=1S/C30H33N5O2/c1-3-13-35(19-22-9-7-21(18-31)8-10-22)30(37)25-15-23-11-12-24(16-27(23)34-28(32)17-25)29(36)33-26-6-4-5-20(2)14-26/h4-12,14-16H,3,13,17-19,31H2,1-2H3,(H2,32,34)(H,33,36)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US9475775 (2016) BindingDB Entry DOI: 10.7270/Q2QC02D4
					More data for this Ligand-Target Pair