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SMILES: CCOC(=O)c1cccc(c1)-c1cncc(Nc2cc(OC)c(OC)c(OC)c2)n1

InChI Key: InChIKey=LAUOTLUUDUQZKV-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25567   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf [V600E]


(Homo sapiens (Human))		BDBM25567
PNG
(2,6-Disubstituted Pyrazine, 9 | ethyl 3-{6-[(3,4,5...)
Show SMILES CCOC(=O)c1cccc(c1)-c1cncc(Nc2cc(OC)c(OC)c(OC)c2)n1
Show InChI InChI=1S/C22H23N3O5/c1-5-30-22(26)15-8-6-7-14(9-15)17-12-23-13-20(25-17)24-16-10-18(27-2)21(29-4)19(11-16)28-3/h6-13H,5H2,1-4H3,(H,24,25)
PDB

UniProtKB/SwissProt

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UniChem

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Article
PubMed
n/an/a 1.40E+4n/an/an/an/a7.222



Cancer Research UK Centre for Cancer Therapeutics



Assay Description
BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...

J Med Chem 51: 3261-74 (2008)


Article DOI: 10.1021/jm070776b
BindingDB Entry DOI: 10.7270/Q2X34VRR
More data for this
Ligand-Target Pair