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SMILES: COc1cc(Nc2cncc(Nc3ccccc3)n2)cc(OC)c1OC

InChI Key: InChIKey=CPNUEMWHACQFFN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25574   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf [V600E]


(Homo sapiens (Human))		BDBM25574
PNG
(2,6-Disubstituted Pyrazine, 20 | 2-N-phenyl-6-N-(3...)
Show SMILES COc1cc(Nc2cncc(Nc3ccccc3)n2)cc(OC)c1OC
Show InChI InChI=1S/C19H20N4O3/c1-24-15-9-14(10-16(25-2)19(15)26-3)22-18-12-20-11-17(23-18)21-13-7-5-4-6-8-13/h4-12H,1-3H3,(H2,21,22,23)
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Article
PubMed
n/an/a 1.60E+4n/an/an/an/a7.222



Cancer Research UK Centre for Cancer Therapeutics



Assay Description
BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...

J Med Chem 51: 3261-74 (2008)


Article DOI: 10.1021/jm070776b
BindingDB Entry DOI: 10.7270/Q2X34VRR
More data for this
Ligand-Target Pair