BDBM25575 2,6-Disubstituted Pyrazine, 21::2-N-(pyridin-4-yl)-6-N-(3,4,5-trimethoxyphenyl)pyrazine-2,6-diamine

SMILES: COc1cc(Nc2cncc(Nc3ccncc3)n2)cc(OC)c1OC

InChI Key: InChIKey=FWUVOKGKHMWHSU-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25575   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human))	BDBM25575 (2,6-Disubstituted Pyrazine, 21 | 2-N-(pyridin-4-yl...) Show SMILES COc1cc(Nc2cncc(Nc3ccncc3)n2)cc(OC)c1OC Show InChI InChI=1S/C18H19N5O3/c1-24-14-8-13(9-15(25-2)18(14)26-3)22-17-11-20-10-16(23-17)21-12-4-6-19-7-5-12/h4-11H,1-3H3,(H2,19,21,22,23)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	7.2	22
Cancer Research UK Centre for Cancer Therapeutics					Assay Description BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...				J Med Chem 51: 3261-74 (2008) Article DOI: 10.1021/jm070776b BindingDB Entry DOI: 10.7270/Q2X34VRR
					More data for this Ligand-Target Pair