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SMILES: COc1cc(Nc2cncc(Nc3cccc(NC(C)=O)c3)n2)cc(OC)c1OC

InChI Key: InChIKey=GCJGSVPTCNTPIN-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25576   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase B-raf [V600E]


(Homo sapiens (Human))		BDBM25576
PNG
(2,6-Disubstituted Pyrazine, 22 | N-[3-({6-[(3,4,5-...)
Show SMILES COc1cc(Nc2cncc(Nc3cccc(NC(C)=O)c3)n2)cc(OC)c1OC
Show InChI InChI=1S/C21H23N5O4/c1-13(27)23-14-6-5-7-15(8-14)24-19-11-22-12-20(26-19)25-16-9-17(28-2)21(30-4)18(10-16)29-3/h5-12H,1-4H3,(H,23,27)(H2,24,25,26)
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Article
PubMed
n/an/a 1.40E+4n/an/an/an/a7.222



Cancer Research UK Centre for Cancer Therapeutics



Assay Description
BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...

J Med Chem 51: 3261-74 (2008)


Article DOI: 10.1021/jm070776b
BindingDB Entry DOI: 10.7270/Q2X34VRR
More data for this
Ligand-Target Pair