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BDBM25580 2,6-Disubstituted Pyrazine, 26::6-(naphthalen-1-yloxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine

SMILES: COc1cc(Nc2cncc(Oc3cccc4ccccc34)n2)cc(OC)c1OC

InChI Key: InChIKey=XHELPAXZVJVVIO-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25580   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
B-RAF V600E


(Homo sapiens (Human))		BDBM25580
PNG
(2,6-Disubstituted Pyrazine, 26 | 6-(naphthalen-1-y...)
Show SMILES COc1cc(Nc2cncc(Oc3cccc4ccccc34)n2)cc(OC)c1OC
Show InChI InChI=1S/C23H21N3O4/c1-27-19-11-16(12-20(28-2)23(19)29-3)25-21-13-24-14-22(26-21)30-18-10-6-8-15-7-4-5-9-17(15)18/h4-14H,1-3H3,(H,25,26)
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Similars
Article
PubMed
n/an/a 1.20E+3n/an/an/an/a7.222



Cancer Research UK Centre for Cancer Therapeutics



Assay Description
BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...

J Med Chem 51: 3261-74 (2008)


Article DOI: 10.1021/jm070776b
BindingDB Entry DOI: 10.7270/Q2X34VRR
More data for this
Ligand-Target Pair