BindingDB logo
myBDB logout

BDBM25583 2,6-Disubstituted Pyrazine, 28::6-(pyridin-4-yloxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine

SMILES: COc1cc(Nc2cncc(Oc3ccncc3)n2)cc(OC)c1OC

InChI Key: InChIKey=KXNQDPMBAZZLDS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25583   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
B-RAF V600E


(Homo sapiens (Human))		BDBM25583
PNG
(2,6-Disubstituted Pyrazine, 28 | 6-(pyridin-4-ylox...)
Show SMILES COc1cc(Nc2cncc(Oc3ccncc3)n2)cc(OC)c1OC
Show InChI InChI=1S/C18H18N4O4/c1-23-14-8-12(9-15(24-2)18(14)25-3)21-16-10-20-11-17(22-16)26-13-4-6-19-7-5-13/h4-11H,1-3H3,(H,21,22)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a 1.60E+4n/an/an/an/a7.222



Cancer Research UK Centre for Cancer Therapeutics



Assay Description
BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...

J Med Chem 51: 3261-74 (2008)


Article DOI: 10.1021/jm070776b
BindingDB Entry DOI: 10.7270/Q2X34VRR
More data for this
Ligand-Target Pair