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BDBM25588 2,6-Disubstituted Pyrazine, 12::3-{6-[(3,4,5-trimethoxyphenyl)amino]pyrazin-2-yl}benzonitrile

SMILES: COc1cc(Nc2cncc(n2)-c2cccc(c2)C#N)cc(OC)c1OC

InChI Key: InChIKey=LZUWHUVYWDFJSH-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25588   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
B-RAF V600E


(Homo sapiens (Human))		BDBM25588
PNG
(2,6-Disubstituted Pyrazine, 12 | 3-{6-[(3,4,5-trim...)
Show SMILES COc1cc(Nc2cncc(n2)-c2cccc(c2)C#N)cc(OC)c1OC
Show InChI InChI=1S/C20H18N4O3/c1-25-17-8-15(9-18(26-2)20(17)27-3)23-19-12-22-11-16(24-19)14-6-4-5-13(7-14)10-21/h4-9,11-12H,1-3H3,(H,23,24)
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Article
PubMed
n/an/a 9.80E+3n/an/an/an/a7.222



Cancer Research UK Centre for Cancer Therapeutics



Assay Description
BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...

J Med Chem 51: 3261-74 (2008)


Article DOI: 10.1021/jm070776b
BindingDB Entry DOI: 10.7270/Q2X34VRR
More data for this
Ligand-Target Pair