BDBM25592 2,6-Disubstituted Pyrazine, 55::6-(quinolin-6-yloxy)-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine

SMILES: COc1cc(Nc2cncc(Oc3ccc4ncccc4c3)n2)cc(OC)c1OC

InChI Key: InChIKey=FKIUEGJLCZHXIT-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25592   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
B-RAF V600E (Homo sapiens (Human))	BDBM25592 (2,6-Disubstituted Pyrazine, 55 | 6-(quinolin-6-ylo...) Show SMILES COc1cc(Nc2cncc(Oc3ccc4ncccc4c3)n2)cc(OC)c1OC Show InChI InChI=1S/C22H20N4O4/c1-27-18-10-15(11-19(28-2)22(18)29-3)25-20-12-23-13-21(26-20)30-16-6-7-17-14(9-16)5-4-8-24-17/h4-13H,1-3H3,(H,25,26)	PDB GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
Cancer Research UK Centre for Cancer Therapeutics					Assay Description BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves...				J Med Chem 51: 3261-74 (2008) Article DOI: 10.1021/jm070776b BindingDB Entry DOI: 10.7270/Q2X34VRR
					More data for this Ligand-Target Pair