BDBM25608 2,6-Disubstituted Pyrazine, 72::6-{4-[(1E)-1-(hydroxyimino)ethyl]phenoxy}-N-(3,4,5-trimethoxyphenyl)pyrazin-2-amine
SMILES: COc1cc(Nc2cncc(Oc3ccc(cc3)C(C)N=O)n2)cc(OC)c1OC
InChI Key: InChIKey=DMPWTEJCEUYONL-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase B-raf [V600E] (Homo sapiens (Human)) | BDBM25608![]() (2,6-Disubstituted Pyrazine, 72 | 6-{4-[(1E)-1-(hyd...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cancer Research UK Centre for Cancer Therapeutics | Assay Description BRAF kinase activity was quantified using a DELFIA-based MEK1 phosphorylation assay. IC50 values were derived from the sigmoidal dose-response curves... | J Med Chem 51: 3261-74 (2008) Article DOI: 10.1021/jm070776b BindingDB Entry DOI: 10.7270/Q2X34VRR | |||||||||||
More data for this Ligand-Target Pair |