BDBM257492 US9493441, 17-4

SMILES: NC(=O)c1cn(nc1Nc1ccnc(F)c1)[C@H](CC#N)C1CC1

InChI Key: InChIKey=RBHGKYJXGOGINC-GFCCVEGCSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 257492   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
GST-JAK2 (Homo sapiens (Human))	BDBM257492 (US9493441, 17-4) Show SMILES NC(=O)c1cn(nc1Nc1ccnc(F)c1)[C@H](CC#N)C1CC1 |r| Show InChI InChI=1S/C15H15FN6O/c16-13-7-10(4-6-19-13)20-15-11(14(18)23)8-22(21-15)12(3-5-17)9-1-2-9/h4,6-9,12H,1-3H2,(H2,18,23)(H,19,20,21)/t12-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US9493441 (2016) BindingDB Entry DOI: 10.7270/Q22J69S2
					More data for this Ligand-Target Pair
GST-JAK1 (Homo sapiens (Human))	BDBM257492 (US9493441, 17-4) Show SMILES NC(=O)c1cn(nc1Nc1ccnc(F)c1)[C@H](CC#N)C1CC1 |r| Show InChI InChI=1S/C15H15FN6O/c16-13-7-10(4-6-19-13)20-15-11(14(18)23)8-22(21-15)12(3-5-17)9-1-2-9/h4,6-9,12H,1-3H2,(H2,18,23)(H,19,20,21)/t12-/m1/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...				US Patent US9493441 (2016) BindingDB Entry DOI: 10.7270/Q22J69S2
					More data for this Ligand-Target Pair