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SMILES: Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)NC2CC2)n(CCCO)c2ncnc(N)c12

InChI Key: InChIKey=NUHQJXSTTZFNIC-LFIBNONCSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 259840   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ribosomal protein S6 kinase alpha-3 [399-740]


(Homo sapiens (Human))		BDBM259840
PNG
(US9505766, 44)
Show SMILES Cc1ccc(cc1)-c1c(\C=C(/C#N)C(=O)NC2CC2)n(CCCO)c2ncnc(N)c12
Show InChI InChI=1S/C23H24N6O2/c1-14-3-5-15(6-4-14)19-18(11-16(12-24)23(31)28-17-7-8-17)29(9-2-10-30)22-20(19)21(25)26-13-27-22/h3-6,11,13,17,30H,2,7-10H2,1H3,(H,28,31)(H2,25,26,27)/b16-11+
UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 2.40n/an/an/an/a8.022



THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

US Patent


Assay Description
RSK2 CTD and His6-ERK2 were expressed and purified as described (Cohen et al., Science, 308: 1318). The C436V mutant of RSK2 CTD was generated by Qui...

US Patent US9505766 (2016)


BindingDB Entry DOI: 10.7270/Q2639NPR
More data for this
Ligand-Target Pair