BDBM259885 US10308662, Compound 126::US9505780, 126
SMILES: Brc1csc2c1oc(cc2=O)N1CCOCC1
InChI Key: InChIKey=QDXOPRNMGJWKAY-UHFFFAOYSA-N
Data: 10 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1) (Homo sapiens (Human)) | BDBM259885![]() (US10308662, Compound 126 | US9505780, 126) | GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 Bromo 2 domain(BRD4 BD2) (Homo sapiens (Human)) | BDBM259885![]() (US10308662, Compound 126 | US9505780, 126) | GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM259885![]() (US10308662, Compound 126 | US9505780, 126) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 889 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM259885![]() (US10308662, Compound 126 | US9505780, 126) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 1.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM259885![]() (US10308662, Compound 126 | US9505780, 126) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai... | J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BRD4 bromodomain 1 (Homo sapiens (Human)) | BDBM259885![]() (US10308662, Compound 126 | US9505780, 126) | PDB MMDB B.MOAD GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai... | J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
BRD4 bromodomain 2 (Homo sapiens (Human)) | BDBM259885![]() (US10308662, Compound 126 | US9505780, 126) | PDB GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai... | J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
PI3-kinase class I (Homo sapiens (Human)) | BDBM259885![]() (US10308662, Compound 126 | US9505780, 126) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 889 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai... | J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM259885![]() (US10308662, Compound 126 | US9505780, 126) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 1.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer | Assay Description Inhibitory activity can be determined routinely using known methods and also from commercial vendors offering this service for kinases and bromodomai... | J Med Chem 50: 2647-54 (2007) BindingDB Entry DOI: 10.7270/Q24170D7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human)) | BDBM259885![]() (US10308662, Compound 126 | US9505780, 126) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase MCE PC cid PC sid UniChem | US Patent | n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair |