BDBM260735 US9533989, 45

SMILES: N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)Oc2ccccc2)n1

InChI Key: InChIKey=GISMNRGGSNCNBH-XZOQPEGZSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 260735   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM260735 (US9533989, 45) Show SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2ccc3CCN(Cc3c2)C(=O)Oc2ccccc2)n1 Show InChI InChI=1S/C27H31N7O3/c28-22-8-4-5-9-23(22)32-26-30-15-21(24(29)35)25(33-26)31-19-11-10-17-12-13-34(16-18(17)14-19)27(36)37-20-6-2-1-3-7-20/h1-3,6-7,10-11,14-15,22-23H,4-5,8-9,12-13,16,28H2,(H2,29,35)(H2,30,31,32,33)/t22-,23+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17.4	n/a	n/a	n/a	n/a	n/a	n/a
Ziarco Pharma Ltd. US Patent					Assay Description The Promega ADP-Glo Kinase Assay is a luminescent ADP detection assay that provides a universal, homogeneous, high-throughput screening method to mea...				US Patent US9533989 (2017) BindingDB Entry DOI: 10.7270/Q2VQ31M7
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