null

SMILES: CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@H](C)O)C(C)n1nc(C)c2c(N)ncnc12

InChI Key: InChIKey=RJWNXJAXIOIPGQ-KZUDCZAMSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 261076   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261076 ((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...) Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@H](C)O)C(C)n1nc(C)c2c(N)ncnc12 |r| Show InChI InChI=1S/C23H29ClN6O3/c1-6-33-20-16(13(4)30-22-19(12(3)28-30)21(25)26-10-27-22)7-17(24)11(2)18(20)15-8-29(9-15)23(32)14(5)31/h7,10,13-15,31H,6,8-9H2,1-5H3,(H2,25,26,27)/t13?,14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261076 ((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...) Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@H](C)O)C(C)n1nc(C)c2c(N)ncnc12 |r| Show InChI InChI=1S/C23H29ClN6O3/c1-6-33-20-16(13(4)30-22-19(12(3)28-30)21(25)26-10-27-22)7-17(24)11(2)18(20)15-8-29(9-15)23(32)14(5)31/h7,10,13-15,31H,6,8-9H2,1-5H3,(H2,25,26,27)/t13?,14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...				US Patent US10092570 (2018) BindingDB Entry DOI: 10.7270/Q2PZ5BW5
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261076 ((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...) Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@H](C)O)C(C)n1nc(C)c2c(N)ncnc12 |r| Show InChI InChI=1S/C23H29ClN6O3/c1-6-33-20-16(13(4)30-22-19(12(3)28-30)21(25)26-10-27-22)7-17(24)11(2)18(20)15-8-29(9-15)23(32)14(5)31/h7,10,13-15,31H,6,8-9H2,1-5H3,(H2,25,26,27)/t13?,14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation; Incyte Holdings Corporation US Patent					Assay Description The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...				US Patent US10646492 (2020)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261076 ((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...) Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@H](C)O)C(C)n1nc(C)c2c(N)ncnc12 |r| Show InChI InChI=1S/C23H29ClN6O3/c1-6-33-20-16(13(4)30-22-19(12(3)28-30)21(25)26-10-27-22)7-17(24)11(2)18(20)15-8-29(9-15)23(32)14(5)31/h7,10,13-15,31H,6,8-9H2,1-5H3,(H2,25,26,27)/t13?,14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Istanbul University					Assay Description The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...				Bioorg Med Chem 16: 9113-20 (2008) BindingDB Entry DOI: 10.7270/Q2SJ1NZ2
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261076 ((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...) Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@H](C)O)C(C)n1nc(C)c2c(N)ncnc12 |r| Show InChI InChI=1S/C23H29ClN6O3/c1-6-33-20-16(13(4)30-22-19(12(3)28-30)21(25)26-10-27-22)7-17(24)11(2)18(20)15-8-29(9-15)23(32)14(5)31/h7,10,13-15,31H,6,8-9H2,1-5H3,(H2,25,26,27)/t13?,14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt...				US Patent US10376513 (2019) BindingDB Entry DOI: 10.7270/Q2GQ7142
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261076 ((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...) Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@H](C)O)C(C)n1nc(C)c2c(N)ncnc12 |r| Show InChI InChI=1S/C23H29ClN6O3/c1-6-33-20-16(13(4)30-22-19(12(3)28-30)21(25)26-10-27-22)7-17(24)11(2)18(20)15-8-29(9-15)23(32)14(5)31/h7,10,13-15,31H,6,8-9H2,1-5H3,(H2,25,26,27)/t13?,14-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd...				US Patent US9730939 (2017) BindingDB Entry DOI: 10.7270/Q2GB265W
					More data for this Ligand-Target Pair