null

SMILES: COc1c(cc(Cl)c(C)c1C1CN(C1)C(O)C(F)(F)F)C(C)n1nc(C)c2c(N)ncnc12

InChI Key: InChIKey=SIWGQKSARWBSPI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 261086   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM261086 (3-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(O)C(F)(F)F)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C21H24ClF3N6O2/c1-9-14(22)5-13(11(3)31-19-16(10(2)29-31)18(26)27-8-28-19)17(33-4)15(9)12-6-30(7-12)20(32)21(23,24)25/h5,8,11-12,20,32H,6-7H2,1-4H3,(H2,26,27,28)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...				Citation and Details BindingDB Entry DOI: 10.7270/Q2417199
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human))	BDBM261086 (3-(3-{3-[1-(4-Amino-3-methyl-1H- pyrazolo[3,4-d]py...) Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(O)C(F)(F)F)C(C)n1nc(C)c2c(N)ncnc12 Show InChI InChI=1S/C21H24ClF3N6O2/c1-9-14(22)5-13(11(3)31-19-16(10(2)29-31)18(26)27-8-28-19)17(33-4)15(9)12-6-30(7-12)20(32)21(23,24)25/h5,8,11-12,20,32H,6-7H2,1-4H3,(H2,26,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	6.7	25
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,...				US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R
					More data for this Ligand-Target Pair