BDBM261096 1-(1-{5-Chloro-3-[1- (cyclopropylcarbonyl)azetidin-3- yl]-2-methoxy-4- methylphenyl}ethyl)-3-methyl-1H- pyrazolo[3,4-d]pyrimidin-4-amine3::US10092570, Example 119::US10376513, Example 119::US10646492, Example 119::US9707233, 119::US9730939, Example 119
SMILES: COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)C1CC1)C(C)n1nc(C)c2c(N)ncnc12
InChI Key: InChIKey=DFZABDFGCIGGKC-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta/delta isoform (Homo sapiens (Human)) | BDBM261096 (1-(1-{5-Chloro-3-[1- (cyclopropylcarbonyl)azetidin...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | 6.7 | 25 |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), are purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isoforms α,... | US Patent US9707233 (2017) BindingDB Entry DOI: 10.7270/Q2S46V0R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM261096 (1-(1-{5-Chloro-3-[1- (cyclopropylcarbonyl)azetidin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | 6.7 | 25 |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt... | US Patent US10092570 (2018) BindingDB Entry DOI: 10.7270/Q2PZ5BW5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM261096 (1-(1-{5-Chloro-3-[1- (cyclopropylcarbonyl)azetidin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Corporation; Incyte Holdings Corporation US Patent | Assay Description The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer... | US Patent US10646492 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM261096 (1-(1-{5-Chloro-3-[1- (cyclopropylcarbonyl)azetidin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation US Patent | Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from Perkin-Elmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Pt... | US Patent US10376513 (2019) BindingDB Entry DOI: 10.7270/Q2GQ7142 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human)) | BDBM261096 (1-(1-{5-Chloro-3-[1- (cyclopropylcarbonyl)azetidin...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | n/a | n/a |
Incyte Holdings Corporation; Incyte Corporation US Patent | Assay Description [γ-33P]ATP (10 mCi/mL) was purchased from PerkinElmer (Waltham, Mass.). Lipid kinase substrate, D-myo-Phosphatidylinositol 4,5-bisphosphate (Ptd... | US Patent US9730939 (2017) BindingDB Entry DOI: 10.7270/Q2GB265W | |||||||||||
More data for this Ligand-Target Pair |