BDBM261685 US9708295, 26
SMILES: COc1cc(cnc1N1CCN(C)C[C@@H]1C)-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1
InChI Key: InChIKey=NBWMSWLCUCBPDT-LSDHHAIUSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM261685 (US9708295, 26) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. US Patent | Assay Description The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic... | US Patent US9708295 (2017) BindingDB Entry DOI: 10.7270/Q2GM899Z | |||||||||||
More data for this Ligand-Target Pair |