BDBM261702 US9708295, 44

SMILES: COc1ccc(nc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNC[C@@H]1C

InChI Key: InChIKey=SLDPPCONXLLAOF-UONOGXRCSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 261702   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM261702 (US9708295, 44) Show SMILES COc1ccc(nc1-c1cnc(N)c(O[C@H](C)c2c(Cl)ccc(F)c2Cl)c1)N1CCNC[C@@H]1C |r| Show InChI InChI=1S/C24H26Cl2FN5O2/c1-13-11-29-8-9-32(13)20-7-6-18(33-3)23(31-20)15-10-19(24(28)30-12-15)34-14(2)21-16(25)4-5-17(27)22(21)26/h4-7,10,12-14,29H,8-9,11H2,1-3H3,(H2,28,30)/t13-,14+/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	60.5	n/a	n/a	n/a	n/a	n/a	n/a
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. US Patent					Assay Description The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic...				US Patent US9708295 (2017) BindingDB Entry DOI: 10.7270/Q2GM899Z
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