BDBM261714 US9708295, 56
SMILES: C[C@@H](Oc1cc(cnc1N)-c1cnc(cc1OCCN1CCOCC1)N1CCNC[C@@H]1C)c1c(Cl)ccc(F)c1Cl
InChI Key: InChIKey=JEIRGBYIAFHYLU-RBUKOAKNSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALK tyrosine kinase receptor (Homo sapiens (Human)) | BDBM261714 (US9708295, 56) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 92.9 | n/a | n/a | n/a | n/a | n/a | n/a |
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.; Centaurus Biopharma Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. US Patent | Assay Description The following method was used to determine ALK kinase inhibitory activity of the compounds of the present invention. The inhibitory activity is indic... | US Patent US9708295 (2017) BindingDB Entry DOI: 10.7270/Q2GM899Z | |||||||||||
More data for this Ligand-Target Pair |