BDBM261831 2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-1H-benzimidazole-5-carboxamide::US9708311, 82

SMILES: CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(N)=O

InChI Key: InChIKey=IXYWOOOEFVLPLX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 261831   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Prostaglandin E2 receptor (Homo sapiens (Human))	BDBM261831 (2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-1H...) Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(N)=O Show InChI InChI=1S/C25H24N4O2/c1-3-28-21-7-5-4-6-18(21)19-14-17(9-10-22(19)28)25-27-20-15-16(24(26)30)8-11-23(20)29(25)12-13-31-2/h4-11,14-15H,3,12-13H2,1-2H3,(H2,26,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	n/a
Bayer AG Curated by ChEMBL					Assay Description Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay				J Med Chem 62: 2541-2563 (2019) Article DOI: 10.1021/acs.jmedchem.8b01862
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM261831 (2-(9-Ethyl-9H-carbazol-3-yl)-1-(2-methoxyethyl)-1H...) Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CCOC)C(N)=O Show InChI InChI=1S/C25H24N4O2/c1-3-28-21-7-5-4-6-18(21)19-14-17(9-10-22(19)28)25-27-20-15-16(24(26)30)8-11-23(20)29(25)12-13-31-2/h4-11,14-15H,3,12-13H2,1-2H3,(H2,26,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	134	n/a	n/a	n/a	n/a	n/a	25
BAYER PHARMA AKTIENGESELLSCHAFT US Patent					Assay Description 4 μl of a cAMP-d2/cell suspension (625000 cells/ml) were added to a test plate containing the substance solutions already initially introduced (...				US Patent US9708311 (2017) BindingDB Entry DOI: 10.7270/Q23F4RPM
					More data for this Ligand-Target Pair