BDBM262163 4-(4-{3- [(dimethylamino) methyl]-5- fluorophenoxy} piperidin-1-yl)- 3-[4-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1- yl]butanenitrile::US9708333, 14

SMILES: CN(C)Cc1cc(F)cc(OC2CCN(CC(CC#N)n3cc(cn3)-c3cccc4[nH]ccc34)CC2)c1

InChI Key: InChIKey=OOCHPFQMTUXFRC-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 262163   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM262163 (4-(4-{3- [(dimethylamino) methyl]-5- fluorophenoxy...) Show SMILES CN(C)Cc1cc(F)cc(OC2CCN(CC(CC#N)n3cc(cn3)-c3cccc4[nH]ccc34)CC2)c1 Show InChI InChI=1S/C29H33FN6O/c1-34(2)18-21-14-23(30)16-26(15-21)37-25-8-12-35(13-9-25)20-24(6-10-31)36-19-22(17-33-36)27-4-3-5-29-28(27)7-11-32-29/h3-5,7,11,14-17,19,24-25,32H,6,8-9,12-13,18,20H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Corporation US Patent					Assay Description As used herein, a selective JAK1 inhibitor is an inhibitor of JAK1 which is selective for JAK1 over JAK2, JAK3 and TYK2. In some embodiments, the com...				US Patent US9708333 (2017) BindingDB Entry DOI: 10.7270/Q2KD20XW
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM262163 (4-(4-{3- [(dimethylamino) methyl]-5- fluorophenoxy...) Show SMILES CN(C)Cc1cc(F)cc(OC2CCN(CC(CC#N)n3cc(cn3)-c3cccc4[nH]ccc34)CC2)c1 Show InChI InChI=1S/C29H33FN6O/c1-34(2)18-21-14-23(30)16-26(15-21)37-25-8-12-35(13-9-25)20-24(6-10-31)36-19-22(17-33-36)27-4-3-5-29-28(27)7-11-32-29/h3-5,7,11,14-17,19,24-25,32H,6,8-9,12-13,18,20H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	25
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US9708333 (2017) BindingDB Entry DOI: 10.7270/Q2KD20XW
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM262163 (4-(4-{3- [(dimethylamino) methyl]-5- fluorophenoxy...) Show SMILES CN(C)Cc1cc(F)cc(OC2CCN(CC(CC#N)n3cc(cn3)-c3cccc4[nH]ccc34)CC2)c1 Show InChI InChI=1S/C29H33FN6O/c1-34(2)18-21-14-23(30)16-26(15-21)37-25-8-12-35(13-9-25)20-24(6-10-31)36-19-22(17-33-36)27-4-3-5-29-28(27)7-11-32-29/h3-5,7,11,14-17,19,24-25,32H,6,8-9,12-13,18,20H2,1-2H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Incyte Corporation US Patent					Assay Description The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolved in DMSO were ...				US Patent US9708333 (2017) BindingDB Entry DOI: 10.7270/Q2KD20XW
					More data for this Ligand-Target Pair