BDBM26229 2-Aminopyrimidine analog., 4::4-[2-amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]benzonitrile::JMC516547 Compound 2

SMILES: CN1CCN(CC1)c1cc(nc(N)n1)-c1ccc(cc1)C#N

InChI Key: InChIKey=QFKQUMBUFVKQBH-UHFFFAOYSA-N

Data: 6 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 26229   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H4 receptor (Homo sapiens (Human))	BDBM26229 (2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...) Show SMILES CN1CCN(CC1)c1cc(nc(N)n1)-c1ccc(cc1)C#N Show InChI InChI=1S/C16H18N6/c1-21-6-8-22(9-7-21)15-10-14(19-16(18)20-15)13-4-2-12(11-17)3-5-13/h2-5,10H,6-9H2,1H3,(H2,18,19,20)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	35	-10.2	n/a	n/a	n/a	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...				J Med Chem 51: 6571-80 (2008) Article DOI: 10.1021/jm8005959 BindingDB Entry DOI: 10.7270/Q24J0CD9
					More data for this Ligand-Target Pair
Histamine H4 receptor (Homo sapiens (Human))	BDBM26229 (2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...) Show SMILES CN1CCN(CC1)c1cc(nc(N)n1)-c1ccc(cc1)C#N Show InChI InChI=1S/C16H18N6/c1-21-6-8-22(9-7-21)15-10-14(19-16(18)20-15)13-4-2-12(11-17)3-5-13/h2-5,10H,6-9H2,1H3,(H2,18,19,20)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	35	-10.2	n/a	n/a	n/a	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...				J Med Chem 51: 6547-57 (2008) Article DOI: 10.1021/jm800670r BindingDB Entry DOI: 10.7270/Q2KH0KM5
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM26229 (2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...) Show SMILES CN1CCN(CC1)c1cc(nc(N)n1)-c1ccc(cc1)C#N Show InChI InChI=1S/C16H18N6/c1-21-6-8-22(9-7-21)15-10-14(19-16(18)20-15)13-4-2-12(11-17)3-5-13/h2-5,10H,6-9H2,1H3,(H2,18,19,20)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	245	-9.01	n/a	n/a	n/a	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...				J Med Chem 51: 6571-80 (2008) Article DOI: 10.1021/jm8005959 BindingDB Entry DOI: 10.7270/Q24J0CD9
					More data for this Ligand-Target Pair
Histamine H4 Receptor (Rattus norvegicus (rat))	BDBM26229 (2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...) Show SMILES CN1CCN(CC1)c1cc(nc(N)n1)-c1ccc(cc1)C#N Show InChI InChI=1S/C16H18N6/c1-21-6-8-22(9-7-21)15-10-14(19-16(18)20-15)13-4-2-12(11-17)3-5-13/h2-5,10H,6-9H2,1H3,(H2,18,19,20)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	275	-8.94	n/a	n/a	n/a	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...				J Med Chem 51: 6571-80 (2008) Article DOI: 10.1021/jm8005959 BindingDB Entry DOI: 10.7270/Q24J0CD9
					More data for this Ligand-Target Pair
Histamine H4 Receptor (Rattus norvegicus (rat))	BDBM26229 (2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...) Show SMILES CN1CCN(CC1)c1cc(nc(N)n1)-c1ccc(cc1)C#N Show InChI InChI=1S/C16H18N6/c1-21-6-8-22(9-7-21)15-10-14(19-16(18)20-15)13-4-2-12(11-17)3-5-13/h2-5,10H,6-9H2,1H3,(H2,18,19,20)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	275	-8.94	n/a	n/a	n/a	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...				J Med Chem 51: 6547-57 (2008) Article DOI: 10.1021/jm800670r BindingDB Entry DOI: 10.7270/Q2KH0KM5
					More data for this Ligand-Target Pair
Histamine H3 receptor (Homo sapiens (Human))	BDBM26229 (2-Aminopyrimidine analog., 4 | 4-[2-amino-6-(4-met...) Show SMILES CN1CCN(CC1)c1cc(nc(N)n1)-c1ccc(cc1)C#N Show InChI InChI=1S/C16H18N6/c1-21-6-8-22(9-7-21)15-10-14(19-16(18)20-15)13-4-2-12(11-17)3-5-13/h2-5,10H,6-9H2,1H3,(H2,18,19,20)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	1.29E+3	-8.03	n/a	n/a	n/a	n/a	n/a	7.4	25
Abbott Laboratories					Assay Description Competition radioligand binding assays were performed with increasing concentrations of test compound in the presence of [3H]ligand. All binding reac...				J Med Chem 51: 6571-80 (2008) Article DOI: 10.1021/jm8005959 BindingDB Entry DOI: 10.7270/Q24J0CD9
					More data for this Ligand-Target Pair