BDBM26312 3-[3-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)phenyl]-1-[3-(trifluoromethyl)phenyl]urea::thieno[3,2-d]pyrimidine analogue, 7

SMILES: FC(F)(F)c1cccc(NC(=O)Nc2cccc(CCNc3ncnc4ccsc34)c2)c1

InChI Key: InChIKey=KUBHVFMGAOITML-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26312   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora Kinase A (Aurora-A) (Mus musculus (mouse))	BDBM26312 (3-[3-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)ph...) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cccc(CCNc3ncnc4ccsc34)c2)c1 Show InChI InChI=1S/C22H18F3N5OS/c23-22(24,25)15-4-2-6-17(12-15)30-21(31)29-16-5-1-3-14(11-16)7-9-26-20-19-18(8-10-32-19)27-13-28-20/h1-6,8,10-13H,7,9H2,(H,26,27,28)(H2,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.2	21
Sunesis Pharmaceuticals					Assay Description Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...				Bioorg Med Chem Lett 18: 4880-4 (2008) Article DOI: 10.1016/j.bmcl.2008.07.073 BindingDB Entry DOI: 10.7270/Q279430N
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