BDBM26316 3-[4-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1,3-thiazol-2-yl]-1-[3-(trifluoromethyl)phenyl]urea::CHEMBL513076::thieno[3,2-d]pyrimidine analogue, 11

SMILES: FC(F)(F)c1cccc(NC(=O)Nc2nc(CCNc3ncnc4ccsc34)cs2)c1

InChI Key: InChIKey=IBZIMOXPGQXXBE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26316   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aurora kinase A (Homo sapiens (Human))	BDBM26316 (3-[4-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2nc(CCNc3ncnc4ccsc34)cs2)c1 Show InChI InChI=1S/C19H15F3N6OS2/c20-19(21,22)11-2-1-3-12(8-11)26-17(29)28-18-27-13(9-31-18)4-6-23-16-15-14(5-7-30-15)24-10-25-16/h1-3,5,7-10H,4,6H2,(H,23,24,25)(H2,26,27,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals (Europe) Ltd. Curated by ChEMBL					Assay Description Inhibition of aurora A kinase				J Med Chem 52: 2629-51 (2009) Checked by Author Article DOI: 10.1021/jm8012129 BindingDB Entry DOI: 10.7270/Q2B85920
					More data for this Ligand-Target Pair
Aurora Kinase A (Aurora-A) (Mus musculus (mouse))	BDBM26316 (3-[4-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...) Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2nc(CCNc3ncnc4ccsc34)cs2)c1 Show InChI InChI=1S/C19H15F3N6OS2/c20-19(21,22)11-2-1-3-12(8-11)26-17(29)28-18-27-13(9-31-18)4-6-23-16-15-14(5-7-30-15)24-10-25-16/h1-3,5,7-10H,4,6H2,(H,23,24,25)(H2,26,27,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.2	21
Sunesis Pharmaceuticals					Assay Description Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...				Bioorg Med Chem Lett 18: 4880-4 (2008) Article DOI: 10.1016/j.bmcl.2008.07.073 BindingDB Entry DOI: 10.7270/Q279430N
					More data for this Ligand-Target Pair