BDBM263691 6- (benzofuran- 5-yl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol6-(2-fluoro- 4- methoxy- phenyl)-5- [4-[(3S)-1- (3- fluoropropyl)- pyrrolidin-3- yl]oxy- phenyl]-8,9- dihydro- 7H- benzo[7]- annulen-2-ol::US9714221, Example 28

SMILES: Oc1ccc2c(CCCC(c3ccc4occc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1

InChI Key: InChIKey=RZAURWDDKRVTEZ-NDEPHWFRSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 263691   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Estrogen receptor (Homo sapiens (Human))	BDBM263691 (6- (benzofuran- 5-yl)-5- [4-[(3S)-1- (3- fluoropro...) Show SMILES Oc1ccc2c(CCCC(c3ccc4occc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 |r,c:20| Show InChI InChI=1S/C32H32FNO3/c33-15-2-16-34-17-13-28(21-34)37-27-9-5-22(6-10-27)32-29(24-7-12-31-25(19-24)14-18-36-31)4-1-3-23-20-26(35)8-11-30(23)32/h5-12,14,18-20,28,35H,1-4,13,15-17,21H2/t28-/m0/s1	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.4	25
SANOFI US Patent					Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...				US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1
					More data for this Ligand-Target Pair
Estrogen receptor alpha Y537S (Homo sapiens (Human))	BDBM263691 (6- (benzofuran- 5-yl)-5- [4-[(3S)-1- (3- fluoropro...) Show SMILES Oc1ccc2c(CCCC(c3ccc4occc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 |r,c:20| Show InChI InChI=1S/C32H32FNO3/c33-15-2-16-34-17-13-28(21-34)37-27-9-5-22(6-10-27)32-29(24-7-12-31-25(19-24)14-18-36-31)4-1-3-23-20-26(35)8-11-30(23)32/h5-12,14,18-20,28,35H,1-4,13,15-17,21H2/t28-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	7.4	25
SANOFI US Patent					Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...				US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1
					More data for this Ligand-Target Pair
Estrogen receptor alpha D538G (Homo sapiens (Human))	BDBM263691 (6- (benzofuran- 5-yl)-5- [4-[(3S)-1- (3- fluoropro...) Show SMILES Oc1ccc2c(CCCC(c3ccc4occc4c3)=C2c2ccc(O[C@H]3CCN(CCCF)C3)cc2)c1 |r,c:20| Show InChI InChI=1S/C32H32FNO3/c33-15-2-16-34-17-13-28(21-34)37-27-9-5-22(6-10-27)32-29(24-7-12-31-25(19-24)14-18-36-31)4-1-3-23-20-26(35)8-11-30(23)32/h5-12,14,18-20,28,35H,1-4,13,15-17,21H2/t28-/m0/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.4	25
SANOFI US Patent					Assay Description It is a competition assay, where binding of a test compound to a complex comprised of (i) His6-ERα298-554 protein representing ERα ligand-b...				US Patent US9714221 (2017) BindingDB Entry DOI: 10.7270/Q2N58PB1
					More data for this Ligand-Target Pair