BDBM263986 2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyrazol-1- yl}pyridine-4-carboxylic acid::US9604961, Example 51::US9714230, 51::US9908865, Example 51

SMILES: Cn1cc2ccc(COc3ccnn3-c3cc(ccn3)C(O)=O)cc2n1

InChI Key: InChIKey=KPTQBEMJSNBGAL-UHFFFAOYSA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 263986   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM263986 (2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...) Show SMILES Cn1cc2ccc(COc3ccnn3-c3cc(ccn3)C(O)=O)cc2n1 Show InChI InChI=1S/C18H15N5O3/c1-22-10-14-3-2-12(8-15(14)21-22)11-26-17-5-7-20-23(17)16-9-13(18(24)25)4-6-19-16/h2-10H,11H2,1H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263986 (2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...) Show SMILES Cn1cc2ccc(COc3ccnn3-c3cc(ccn3)C(O)=O)cc2n1 Show InChI InChI=1S/C18H15N5O3/c1-22-10-14-3-2-12(8-15(14)21-22)11-26-17-5-7-20-23(17)16-9-13(18(24)25)4-6-19-16/h2-10H,11H2,1H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263986 (2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...) Show SMILES Cn1cc2ccc(COc3ccnn3-c3cc(ccn3)C(O)=O)cc2n1 Show InChI InChI=1S/C18H15N5O3/c1-22-10-14-3-2-12(8-15(14)21-22)11-26-17-5-7-20-23(17)16-9-13(18(24)25)4-6-19-16/h2-10H,11H2,1H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM263986 (2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...) Show SMILES Cn1cc2ccc(COc3ccnn3-c3cc(ccn3)C(O)=O)cc2n1 Show InChI InChI=1S/C18H15N5O3/c1-22-10-14-3-2-12(8-15(14)21-22)11-26-17-5-7-20-23(17)16-9-13(18(24)25)4-6-19-16/h2-10H,11H2,1H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263986 (2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...) Show SMILES Cn1cc2ccc(COc3ccnn3-c3cc(ccn3)C(O)=O)cc2n1 Show InChI InChI=1S/C18H15N5O3/c1-22-10-14-3-2-12(8-15(14)21-22)11-26-17-5-7-20-23(17)16-9-13(18(24)25)4-6-19-16/h2-10H,11H2,1H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	550	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263986 (2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...) Show SMILES Cn1cc2ccc(COc3ccnn3-c3cc(ccn3)C(O)=O)cc2n1 Show InChI InChI=1S/C18H15N5O3/c1-22-10-14-3-2-12(8-15(14)21-22)11-26-17-5-7-20-23(17)16-9-13(18(24)25)4-6-19-16/h2-10H,11H2,1H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM263986 (2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...) Show SMILES Cn1cc2ccc(COc3ccnn3-c3cc(ccn3)C(O)=O)cc2n1 Show InChI InChI=1S/C18H15N5O3/c1-22-10-14-3-2-12(8-15(14)21-22)11-26-17-5-7-20-23(17)16-9-13(18(24)25)4-6-19-16/h2-10H,11H2,1H3,(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263986 (2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...) Show SMILES Cn1cc2ccc(COc3ccnn3-c3cc(ccn3)C(O)=O)cc2n1 Show InChI InChI=1S/C18H15N5O3/c1-22-10-14-3-2-12(8-15(14)21-22)11-26-17-5-7-20-23(17)16-9-13(18(24)25)4-6-19-16/h2-10H,11H2,1H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263986 (2-{5-[(1-methyl-1H-indazol-6- yl)methoxy]-1H-pyraz...) Show SMILES Cn1cc2ccc(COc3ccnn3-c3cc(ccn3)C(O)=O)cc2n1 Show InChI InChI=1S/C18H15N5O3/c1-22-10-14-3-2-12(8-15(14)21-22)11-26-17-5-7-20-23(17)16-9-13(18(24)25)4-6-19-16/h2-10H,11H2,1H3,(H,24,25)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair