BDBM263996 2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridine-4-carboxylic acid::US10173996, Example 61::US9604961, Example 61::US9714230, 61::US9908865, Example 61

SMILES: OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1

InChI Key: InChIKey=ONEZLZXKPNGPFV-UHFFFAOYSA-N

Data: 12 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 263996   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM263996 (2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1 Show InChI InChI=1S/C15H12N4O3/c20-15(21)12-3-7-17-13(9-12)19-14(4-8-18-19)22-10-11-1-5-16-6-2-11/h1-9H,10H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263996 (2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1 Show InChI InChI=1S/C15H12N4O3/c20-15(21)12-3-7-17-13(9-12)19-14(4-8-18-19)22-10-11-1-5-16-6-2-11/h1-9H,10H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263996 (2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1 Show InChI InChI=1S/C15H12N4O3/c20-15(21)12-3-7-17-13(9-12)19-14(4-8-18-19)22-10-11-1-5-16-6-2-11/h1-9H,10H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM263996 (2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1 Show InChI InChI=1S/C15H12N4O3/c20-15(21)12-3-7-17-13(9-12)19-14(4-8-18-19)22-10-11-1-5-16-6-2-11/h1-9H,10H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263996 (2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1 Show InChI InChI=1S/C15H12N4O3/c20-15(21)12-3-7-17-13(9-12)19-14(4-8-18-19)22-10-11-1-5-16-6-2-11/h1-9H,10H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263996 (2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1 Show InChI InChI=1S/C15H12N4O3/c20-15(21)12-3-7-17-13(9-12)19-14(4-8-18-19)22-10-11-1-5-16-6-2-11/h1-9H,10H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM263996 (2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1 Show InChI InChI=1S/C15H12N4O3/c20-15(21)12-3-7-17-13(9-12)19-14(4-8-18-19)22-10-11-1-5-16-6-2-11/h1-9H,10H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263996 (2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1 Show InChI InChI=1S/C15H12N4O3/c20-15(21)12-3-7-17-13(9-12)19-14(4-8-18-19)22-10-11-1-5-16-6-2-11/h1-9H,10H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263996 (2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1 Show InChI InChI=1S/C15H12N4O3/c20-15(21)12-3-7-17-13(9-12)19-14(4-8-18-19)22-10-11-1-5-16-6-2-11/h1-9H,10H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM263996 (2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1 Show InChI InChI=1S/C15H12N4O3/c20-15(21)12-3-7-17-13(9-12)19-14(4-8-18-19)22-10-11-1-5-16-6-2-11/h1-9H,10H2,(H,20,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM263996 (2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1 Show InChI InChI=1S/C15H12N4O3/c20-15(21)12-3-7-17-13(9-12)19-14(4-8-18-19)22-10-11-1-5-16-6-2-11/h1-9H,10H2,(H,20,21)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM263996 (2-[5-(pyridin-4-ylmethoxy)-1H- pyrazol-1-yl]pyridi...) Show SMILES OC(=O)c1ccnc(c1)-n1nccc1OCc1ccncc1 Show InChI InChI=1S/C15H12N4O3/c20-15(21)12-3-7-17-13(9-12)19-14(4-8-18-19)22-10-11-1-5-16-6-2-11/h1-9H,10H2,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair