BDBM264071 2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl]pyrazol-1- yl]pyridine-4-carboxylic acid::US10173996, Example 156::US9604961, Example 156::US9714230, 156::US9908865, Example 156

SMILES: CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1

InChI Key: InChIKey=NMDDEKBJKMJOQQ-UHFFFAOYSA-N

Data: 16 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 264071   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<10	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US9604961 (2017) BindingDB Entry DOI: 10.7270/Q2KP847M
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 2B (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Quanticel Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of FBXL10 was determined in 384-well plate format under the following reaction conditions: 0.3 ...				US Patent US10173996 (2019) BindingDB Entry DOI: 10.7270/Q2CJ8GK0
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5A (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The enzymatic assay of Jarid1A activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test c...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 4C (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q29Z9762
					More data for this Ligand-Target Pair
Lysine-specific demethylase 5B (Homo sapiens (Human))	BDBM264071 (2-[4-(2-[(4-fluorophenyl)methyl- methylamino]ethyl...) Show SMILES CN(CCc1cnn(c1)-c1cc(ccn1)C(O)=O)Cc1ccc(F)cc1 Show InChI InChI=1S/C19H19FN4O2/c1-23(12-14-2-4-17(20)5-3-14)9-7-15-11-22-24(13-15)18-10-16(19(25)26)6-8-21-18/h2-6,8,10-11,13H,7,9,12H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	25
Celgene Quantical Research, Inc. US Patent					Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8...				US Patent US9714230 (2017) BindingDB Entry DOI: 10.7270/Q2CR5WC6
					More data for this Ligand-Target Pair