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SMILES: COc1cc(Nc2nc(NCc3ccco3)n3ccnc3c2C(N)=O)cc(OC)c1

InChI Key: InChIKey=KQLMFPACBDBFHV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 26417   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM26417 (7-[(3,5-dimethoxyphenyl)amino]-5-[(furan-2-ylmethy...) Show SMILES COc1cc(Nc2nc(NCc3ccco3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C20H20N6O4/c1-28-14-8-12(9-15(10-14)29-2)24-18-16(17(21)27)19-22-5-6-26(19)20(25-18)23-11-13-4-3-7-30-13/h3-10,24H,11H2,1-2H3,(H2,21,27)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used, wherein ADP generated by Syk kinase was converted to ATP by pyruvate kinase (PK), with concomitant produ...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair
Tyrosine-protein kinase ZAP-70 (Homo sapiens (Human))	BDBM26417 (7-[(3,5-dimethoxyphenyl)amino]-5-[(furan-2-ylmethy...) Show SMILES COc1cc(Nc2nc(NCc3ccco3)n3ccnc3c2C(N)=O)cc(OC)c1 Show InChI InChI=1S/C20H20N6O4/c1-28-14-8-12(9-15(10-14)29-2)24-18-16(17(21)27)19-22-5-6-26(19)20(25-18)23-11-13-4-3-7-30-13/h3-10,24H,11H2,1-2H3,(H2,21,27)(H,23,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	920	n/a	n/a	n/a	n/a	7.6	30
Kissei Pharmaceutical Company					Assay Description A coupled spectrophotometric assay was used wherein ADP generated by ZAP-70 kinase was converted to ATP by pyruvate kinase (PK), with concomitant pro...				Bioorg Med Chem 17: 284-94 (2009) Article DOI: 10.1016/j.bmc.2008.10.070 BindingDB Entry DOI: 10.7270/Q2FQ9TXB
					More data for this Ligand-Target Pair