BDBM264191 (2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-ethoxy- 1-methyl-1H-pyrazol- 4-yl)amino]-5- fluoropyrimidin-4-yl}-1H- indol-7-yl)propanamide::US10167276, Example 12::US10654835, Example 12::US9714236, 12

SMILES: CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12

InChI Key:

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 264191   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
JAK1 (aa 866-1154) (Homo sapiens (Human))	BDBM264191 ((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...) Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 |r| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	68	n/a	n/a	n/a	n/a	7.3	n/a
ASTRAZENECA AB US Patent					Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...				US Patent US9714236 (2017) BindingDB Entry DOI: 10.7270/Q2VQ34PC
					More data for this Ligand-Target Pair
JAK2 (aa 831-1132) (Homo sapiens (Human))	BDBM264191 ((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...) Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 |r| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.26E+4	n/a	n/a	n/a	n/a	7.3	n/a
ASTRAZENECA AB US Patent					Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...				US Patent US9714236 (2017) BindingDB Entry DOI: 10.7270/Q2VQ34PC
					More data for this Ligand-Target Pair
JAK3 (aa 781-1124) (Homo sapiens (Human))	BDBM264191 ((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...) Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 |r| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	7.3	n/a
ASTRAZENECA AB US Patent					Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...				US Patent US9714236 (2017) BindingDB Entry DOI: 10.7270/Q2VQ34PC
					More data for this Ligand-Target Pair
JAK1 (aa 866-1154) (Homo sapiens (Human))	BDBM264191 ((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...) Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 |r| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Dizal (Jiangsu) Pharmaceutical Co., Ltd. US Patent					Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...				US Patent US10167276 (2019) BindingDB Entry DOI: 10.7270/Q20R9RG0
					More data for this Ligand-Target Pair
JAK3 (aa 781-1124) (Homo sapiens (Human))	BDBM264191 ((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...) Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 |r| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dizal (Jiangsu) Pharmaceutical Co., Ltd. US Patent					Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...				US Patent US10654835 (2020)
					More data for this Ligand-Target Pair
JAK3 (aa 811-1124) (Homo sapiens (Human))	BDBM264191 ((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...) Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 |r| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dizal (Jiangsu) Pharmaceutical Co., Ltd. US Patent					Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...				US Patent US10167276 (2019) BindingDB Entry DOI: 10.7270/Q20R9RG0
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (aa 866-1154) (Homo sapiens (Human))	BDBM264191 ((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...) Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Dizal (Jiangsu) Pharmaceutical Co., Ltd. US Patent					Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...				US Patent US10654835 (2020)
					More data for this Ligand-Target Pair
JAK2 (aa 831-1132) (Homo sapiens (Human))	BDBM264191 ((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...) Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 |r| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dizal (Jiangsu) Pharmaceutical Co., Ltd. US Patent					Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...				US Patent US10654835 (2020)
					More data for this Ligand-Target Pair
JAK2 (aa 808-1132) (Homo sapiens (Human))	BDBM264191 ((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...) Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12 |r| Show InChI	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.26E+4	n/a	n/a	n/a	n/a	n/a	n/a
Dizal (Jiangsu) Pharmaceutical Co., Ltd. US Patent					Assay Description Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...				US Patent US10167276 (2019) BindingDB Entry DOI: 10.7270/Q20R9RG0
					More data for this Ligand-Target Pair