BDBM26573 (3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazolo[1,5-a]pyridin-3-yl]methyl}benzene)oxane-3,4-dicarboxamide::pyrazolopyridine, 47

SMILES: CC(C)c1nn2ccccc2c1Cc1ccc(cc1)C(=O)N[C@@H]1CCOC[C@@H]1C(=O)NO

InChI Key: InChIKey=FLPIBFXJTDQPCO-VQTJNVASSA-N

Data: 4 KI  1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26573   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Matrix metalloproteinase-12 (MMP12) (Homo sapiens (Human))	BDBM26573 ((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazo...) Show SMILES CC(C)c1nn2ccccc2c1Cc1ccc(cc1)C(=O)N[C@@H]1CCOC[C@@H]1C(=O)NO |r| Show InChI InChI=1S/C24H28N4O4/c1-15(2)22-18(21-5-3-4-11-28(21)26-22)13-16-6-8-17(9-7-16)23(29)25-20-10-12-32-14-19(20)24(30)27-31/h3-9,11,15,19-20,31H,10,12-14H2,1-2H3,(H,25,29)(H,27,30)/t19-,20+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	119	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...				Bioorg Med Chem Lett 18: 1958-62 (2008) Article DOI: 10.1016/j.bmcl.2008.01.120 BindingDB Entry DOI: 10.7270/Q25B00SX
					More data for this Ligand-Target Pair
Matrix metalloproteinase-7 (MMP7) (Homo sapiens (Human))	BDBM26573 ((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazo...) Show SMILES CC(C)c1nn2ccccc2c1Cc1ccc(cc1)C(=O)N[C@@H]1CCOC[C@@H]1C(=O)NO |r| Show InChI InChI=1S/C24H28N4O4/c1-15(2)22-18(21-5-3-4-11-28(21)26-22)13-16-6-8-17(9-7-16)23(29)25-20-10-12-32-14-19(20)24(30)27-31/h3-9,11,15,19-20,31H,10,12-14H2,1-2H3,(H,25,29)(H,27,30)/t19-,20+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.65E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...				Bioorg Med Chem Lett 18: 1958-62 (2008) Article DOI: 10.1016/j.bmcl.2008.01.120 BindingDB Entry DOI: 10.7270/Q25B00SX
					More data for this Ligand-Target Pair
Stromelysin-1 (Homo sapiens (Human))	BDBM26573 ((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazo...) Show SMILES CC(C)c1nn2ccccc2c1Cc1ccc(cc1)C(=O)N[C@@H]1CCOC[C@@H]1C(=O)NO |r| Show InChI InChI=1S/C24H28N4O4/c1-15(2)22-18(21-5-3-4-11-28(21)26-22)13-16-6-8-17(9-7-16)23(29)25-20-10-12-32-14-19(20)24(30)27-31/h3-9,11,15,19-20,31H,10,12-14H2,1-2H3,(H,25,29)(H,27,30)/t19-,20+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	3.31E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Company					Assay Description The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...				Bioorg Med Chem Lett 18: 1958-62 (2008) Article DOI: 10.1016/j.bmcl.2008.01.120 BindingDB Entry DOI: 10.7270/Q25B00SX
					More data for this Ligand-Target Pair
72 kDa type IV collagenase (Homo sapiens (Human))	BDBM26573 ((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazo...) Show SMILES CC(C)c1nn2ccccc2c1Cc1ccc(cc1)C(=O)N[C@@H]1CCOC[C@@H]1C(=O)NO |r| Show InChI InChI=1S/C24H28N4O4/c1-15(2)22-18(21-5-3-4-11-28(21)26-22)13-16-6-8-17(9-7-16)23(29)25-20-10-12-32-14-19(20)24(30)27-31/h3-9,11,15,19-20,31H,10,12-14H2,1-2H3,(H,25,29)(H,27,30)/t19-,20+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	>3.33E+3	>-7.47	n/a	n/a	n/a	n/a	n/a	7.5	25
Bristol-Myers Squibb Company					Assay Description The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...				Bioorg Med Chem Lett 18: 1958-62 (2008) Article DOI: 10.1016/j.bmcl.2008.01.120 BindingDB Entry DOI: 10.7270/Q25B00SX
					More data for this Ligand-Target Pair
ADAM17 (Sus scrofa (pig))	BDBM26573 ((3R,4R)-3-N-hydroxy-4-N-(4-{[2-(propan-2-yl)pyrazo...) Show SMILES CC(C)c1nn2ccccc2c1Cc1ccc(cc1)C(=O)N[C@@H]1CCOC[C@@H]1C(=O)NO |r| Show InChI InChI=1S/C24H28N4O4/c1-15(2)22-18(21-5-3-4-11-28(21)26-22)13-16-6-8-17(9-7-16)23(29)25-20-10-12-32-14-19(20)24(30)27-31/h3-9,11,15,19-20,31H,10,12-14H2,1-2H3,(H,25,29)(H,27,30)/t19-,20+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.5	25
Bristol-Myers Squibb Company					Assay Description The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...				Bioorg Med Chem Lett 18: 1958-62 (2008) Article DOI: 10.1016/j.bmcl.2008.01.120 BindingDB Entry DOI: 10.7270/Q25B00SX
					More data for this Ligand-Target Pair