BDBM26640 (5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolidine-2,4-dione::thiazolidine-2,4-dione, 18a

SMILES: OC1=NC(=O)C(S1)=Cc1ccc(F)cc1

InChI Key: InChIKey=XQEXVSOHLCLCFH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26640   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM26640 ((5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolid...) Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(F)cc1 |w:7.8,t:1| Show InChI InChI=1S/C10H6FNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	7.0	25
Medical University of South Carolina					Assay Description The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...				J Med Chem 52: 74-86 (2009) Article DOI: 10.1021/jm800937p BindingDB Entry DOI: 10.7270/Q2S180SF
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 1 (TDP1) (Homo sapiens (Human))	BDBM26640 ((5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolid...) Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(F)cc1 |w:7.8,t:1| Show InChI InChI=1S/C10H6FNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.33E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of human recombinant Tdp1 assessed as conversion of 14-mer 5'-32P-labeled 3'-phosphotyrosyl DNA substrate N14Y to 14-mer 5'-32P-labeled 3'...				J Med Chem 55: 8671-84 (2012) Article DOI: 10.1021/jm3008773 BindingDB Entry DOI: 10.7270/Q2MP54D1
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM26640 ((5Z)-5-[(4-fluorophenyl)methylidene]-1,3-thiazolid...) Show SMILES OC1=NC(=O)C(S1)=Cc1ccc(F)cc1 |w:7.8,t:1| Show InChI InChI=1S/C10H6FNO2S/c11-7-3-1-6(2-4-7)5-8-9(13)12-10(14)15-8/h1-5H,(H,12,13,14)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Medical University of South Carolina					Assay Description The primary screen and evaluation of the compounds was conducted using an ATP-depletion assay. Recombinant human Pim kinase was incubated with S6 kin...				J Med Chem 52: 74-86 (2009) Article DOI: 10.1021/jm800937p BindingDB Entry DOI: 10.7270/Q2S180SF
					More data for this Ligand-Target Pair