BDBM26689 2-keto-4-(4-pyridyl)-1,5-dihydrochromeno[4,3-b]pyridine-3-carbonitrile::2-oxidanylidene-4-pyridin-4-yl-1,5-dihydrochromeno[4,3-b]pyridine-3-carbonitrile::2-oxo-4-(4-pyridinyl)-1,5-dihydro-2H-chromeno[4,3-b]pyridine-3-carbonitrile::2-oxo-4-pyridin-4-yl-1,5-dihydro[1]benzopyrano[4,3-b]pyridine-3-carbonitrile::2-oxo-4-pyridin-4-yl-1,5-dihydrochromeno[4,3-b]pyridine-3-carbonitrile::4-oxo-6-(pyridin-4-yl)-9-oxa-3-azatricyclo[8.4.0.0^{2,7}]tetradeca-1(10),2(7),5,11,13-pentaene-5-carbonitrile::MLS000850511::SMR000456529::cid_2816447::pyridone-based compound, 17

SMILES: O=c1[nH]c-2c(COc3ccccc-23)c(-c2ccncc2)c1C#N

InChI Key: InChIKey=GXUJILPZVBWOIY-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 26689   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM26689 (2-keto-4-(4-pyridyl)-1,5-dihydrochromeno[4,3-b]pyr...) Show SMILES O=c1[nH]c-2c(COc3ccccc-23)c(-c2ccncc2)c1C#N Show InChI InChI=1S/C18H11N3O2/c19-9-13-16(11-5-7-20-8-6-11)14-10-23-15-4-2-1-3-12(15)17(14)21-18(13)22/h1-8H,10H2,(H,21,22)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	7.5	23
Valeant Pharmaceuticals Research and Development					Assay Description PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...				Bioorg Med Chem Lett 17: 1679-83 (2007) Article DOI: 10.1016/j.bmcl.2006.12.086 BindingDB Entry DOI: 10.7270/Q2CV4G2V
					More data for this Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C (Homo sapiens (Human))	BDBM26689 (2-keto-4-(4-pyridyl)-1,5-dihydrochromeno[4,3-b]pyr...) Show SMILES O=c1[nH]c-2c(COc3ccccc-23)c(-c2ccncc2)c1C#N Show InChI InChI=1S/C18H11N3O2/c19-9-13-16(11-5-7-20-8-6-11)14-10-23-15-4-2-1-3-12(15)17(14)21-18(13)22/h1-8H,10H2,(H,21,22)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	7.4	23
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description This assay is to use HTS to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC, a potential thera...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2DV1H7P
					More data for this Ligand-Target Pair
Runt-Related Transcription Factor 1 Isoform AML1C (Homo sapiens (Human))	BDBM26689 (2-keto-4-(4-pyridyl)-1,5-dihydrochromeno[4,3-b]pyr...) Show SMILES O=c1[nH]c-2c(COc3ccccc-23)c(-c2ccncc2)c1C#N Show InChI InChI=1S/C18H11N3O2/c19-9-13-16(11-5-7-20-8-6-11)14-10-23-15-4-2-1-3-12(15)17(14)21-18(13)22/h1-8H,10H2,(H,21,22)	PDB MMDB NCI pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	PCBioAssay	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	7.4	23
Burnham Center for Chemical Genomics Curated by PubChem BioAssay					Assay Description This assay is to identify inhibitors of the protein-protein interaction between the RUNX1 Runt domain and CBFbeta-SMMHC. This is accomplished by usin...				PubChem Bioassay (2009) BindingDB Entry DOI: 10.7270/Q2T72FSX
					More data for this Ligand-Target Pair