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SMILES: CCOC(=O)C1=C2C(N(C)C(=O)C1)c1ccccc1OC2=O

InChI Key: InChIKey=YQUCNCKNGPDWCY-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26696   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))		BDBM26696
PNG
(ethyl 3-methyl-4,8-dioxo-9-oxa-3-azatricyclo[8.4.0...)
Show SMILES CCOC(=O)C1=C2C(N(C)C(=O)C1)c1ccccc1OC2=O |t:5|
Show InChI InChI=1S/C16H15NO5/c1-3-21-15(19)10-8-12(18)17(2)14-9-6-4-5-7-11(9)22-16(20)13(10)14/h4-7,14H,3,8H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.00E+4n/an/an/an/a7.523



Valeant Pharmaceuticals Research and Development



Assay Description
PIM-1 kinase activity was evaluated using calf thymus histones as the substrate in a 96-well filter plate format. After incubation, the plate was was...

Bioorg Med Chem Lett 17: 1679-83 (2007)


Article DOI: 10.1016/j.bmcl.2006.12.086
BindingDB Entry DOI: 10.7270/Q2CV4G2V
More data for this
Ligand-Target Pair