BDBM267446 US9718822, 29::US9750744, Example 29::US9902741, Example 29

SMILES: CCNC(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2

InChI Key: InChIKey=RZZSLWWLMQHIEZ-GOSISDBHSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 267446   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267446 (US9718822, 29 | US9750744, Example 29 | US9902741,...) Show SMILES CCNC(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C22H25FN6O2/c1-2-24-22(30)27-10-11-31-19-6-5-16(23)12-17(19)18-4-3-8-28(18)20-7-9-29-21(26-20)15(14-27)13-25-29/h5-7,9,12-13,18H,2-4,8,10-11,14H2,1H3,(H,24,30)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9718822 (2017) BindingDB Entry DOI: 10.7270/Q2N3000J
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267446 (US9718822, 29 | US9750744, Example 29 | US9902741,...) Show SMILES CCNC(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C22H25FN6O2/c1-2-24-22(30)27-10-11-31-19-6-5-16(23)12-17(19)18-4-3-8-28(18)20-7-9-29-21(26-20)15(14-27)13-25-29/h5-7,9,12-13,18H,2-4,8,10-11,14H2,1H3,(H,24,30)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors Immulon 4HBX 384-well microtiter p...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q21N83FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267446 (US9718822, 29 | US9750744, Example 29 | US9902741,...) Show SMILES CCNC(=O)N1CCOc2ccc(F)cc2[C@H]2CCCN2c2ccn3ncc(C1)c3n2 |r| Show InChI InChI=1S/C22H25FN6O2/c1-2-24-22(30)27-10-11-31-19-6-5-16(23)12-17(19)18-4-3-8-28(18)20-7-9-29-21(26-20)15(14-27)13-25-29/h5-7,9,12-13,18H,2-4,8,10-11,14H2,1H3,(H,24,30)/t18-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair