BDBM267447 US9718822, 30::US9750744, Example 30::US9902741, Example 30

SMILES: Fc1cnc2OCCCNC(=O)c3cnn4ccc(nc34)N3[C@H](COC3=O)c2c1

InChI Key: InChIKey=HODOGORARXFPKU-CYBMUJFWSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 267447   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267447 (US9718822, 30 | US9750744, Example 30 | US9902741,...) Show SMILES Fc1cnc2OCCCNC(=O)c3cnn4ccc(nc34)N3[C@H](COC3=O)c2c1 |r| Show InChI InChI=1S/C18H15FN6O4/c19-10-6-11-13-9-29-18(27)25(13)14-2-4-24-15(23-14)12(8-22-24)16(26)20-3-1-5-28-17(11)21-7-10/h2,4,6-8,13H,1,3,5,9H2,(H,20,26)/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9718822 (2017) BindingDB Entry DOI: 10.7270/Q2N3000J
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267447 (US9718822, 30 | US9750744, Example 30 | US9902741,...) Show SMILES Fc1cnc2OCCCNC(=O)c3cnn4ccc(nc34)N3[C@H](COC3=O)c2c1 |r| Show InChI InChI=1S/C18H15FN6O4/c19-10-6-11-13-9-29-18(27)25(13)14-2-4-24-15(23-14)12(8-22-24)16(26)20-3-1-5-28-17(11)21-7-10/h2,4,6-8,13H,1,3,5,9H2,(H,20,26)/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors Immulon 4HBX 384-well microtiter p...				J Med Chem 48: 2906-15 (2005) BindingDB Entry DOI: 10.7270/Q21N83FK
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM267447 (US9718822, 30 | US9750744, Example 30 | US9902741,...) Show SMILES Fc1cnc2OCCCNC(=O)c3cnn4ccc(nc34)N3[C@H](COC3=O)c2c1 |r| Show InChI InChI=1S/C18H15FN6O4/c19-10-6-11-13-9-29-18(27)25(13)14-2-4-24-15(23-14)12(8-22-24)16(26)20-3-1-5-28-17(11)21-7-10/h2,4,6-8,13H,1,3,5,9H2,(H,20,26)/t13-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9750744 (2017) BindingDB Entry DOI: 10.7270/Q2C82CFX
					More data for this Ligand-Target Pair