BDBM270517 (S)-3-(((2-methyl-6-(o-tolyl)-1,2,3,4-tetrahydro-isoquinolin-1-yl)methyl)amino)isonicotinic acid::US10059687, Example 12B
SMILES: CN1CCc2cc(ccc2[C@H]1CNc1cnccc1C(O)=O)-c1ccccc1C
InChI Key: InChIKey=OFBGWHODICLZJS-HSZRJFAPSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM270517 ((S)-3-(((2-methyl-6-(o-tolyl)-1,2,3,4-tetrahydro-i...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditions: 0.3 ... | US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 6B (Homo sapiens (Human)) | BDBM270517 ((S)-3-(((2-methyl-6-(o-tolyl)-1,2,3,4-tetrahydro-i...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of test com... | US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM270517 ((S)-3-(((2-methyl-6-(o-tolyl)-1,2,3,4-tetrahydro-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
CELGENE QUANTICEL RESEARCH, INC. US Patent | Assay Description Jarid1b: The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction condit... | US Patent US11001568 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 4C (Homo sapiens (Human)) | BDBM270517 ((S)-3-(((2-methyl-6-(o-tolyl)-1,2,3,4-tetrahydro-i...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CELGENE QUANTICEL RESEARCH, INC. US Patent | Assay Description JMJD2C: The ability of test compounds to inhibit the activity of JMJD2C was determined in 384-well plate format under the following reaction conditio... | US Patent US11001568 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 6B (Homo sapiens (Human)) | BDBM270517 ((S)-3-(((2-methyl-6-(o-tolyl)-1,2,3,4-tetrahydro-i...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
CELGENE QUANTICEL RESEARCH, INC. US Patent | Assay Description JMJD3: The enzymatic assay of JMJD3 activity is based upon Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The ability of t... | US Patent US11001568 (2021) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Lysine-specific demethylase 5B (Homo sapiens (Human)) | BDBM270517 ((S)-3-(((2-methyl-6-(o-tolyl)-1,2,3,4-tetrahydro-i...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Quanticel Research, Inc. US Patent | Assay Description The ability of test compounds to inhibit the activity of Jarid1B was determined in 384-well plate format under the following reaction conditions: 0.8... | US Patent US10059687 (2018) BindingDB Entry DOI: 10.7270/Q2TM7D54 | |||||||||||
More data for this Ligand-Target Pair |