BDBM271459 2-(1-(cyclopropylmethyl)-4-hydroxy-2-oxo-7-phenoxy-1,2-dihydroquinoline-3-carboxamido)acetic acid::US10065928, Example 2
SMILES: OC(=O)CNC(=O)c1c(O)c2ccc(Oc3ccccc3)cc2n(CC2CC2)c1=O
InChI Key: InChIKey=ZVGIBRLEWHRJAY-UHFFFAOYSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human)) | BDBM271459 (2-(1-(cyclopropylmethyl)-4-hydroxy-2-oxo-7-phenoxy...) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a |
SUNSHINE LAKE PHARMA CO., LTD. US Patent | Assay Description The activities of compounds of the invention in inducing erythropoietin (EPO) production were assessed by using human live cancer cell strain Hep3B (... | US Patent US10065928 (2018) BindingDB Entry DOI: 10.7270/Q2DB83WQ | |||||||||||
More data for this Ligand-Target Pair |