BDBM272085 (S)-2-(4-(Difluoromethoxy)phenyl)-5-(3-fluoro-2- methylphenyl)-N-hydroxy-2,4,5,6- tetrahydrocyclopenta[c]pyrazole-5-carboxamide::US10065948, 21::US10457675, Example 21

SMILES: Cc1c(F)cccc1[C@@]1(Cc2cn(nc2C1)-c1ccc(OC(F)F)cc1)C(=O)NO

InChI Key: InChIKey=SFEDPGYRMDCTPN-NRFANRHFSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 272085   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone deacetylase 9 (Homo sapiens (Human))	BDBM272085 ((S)-2-(4-(Difluoromethoxy)phenyl)-5-(3-fluoro-2- m...) Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cn(nc2C1)-c1ccc(OC(F)F)cc1)C(=O)NO |r| Show InChI InChI=1S/C21H18F3N3O3/c1-12-16(3-2-4-17(12)22)21(19(28)26-29)9-13-11-27(25-18(13)10-21)14-5-7-15(8-6-14)30-20(23)24/h2-8,11,20,29H,9-10H2,1H3,(H,26,28)/t21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	147	n/a	n/a	n/a	n/a	n/a	n/a
CHDI Foundation, Inc. US Patent					Assay Description The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...				US Patent US10457675 (2019) BindingDB Entry DOI: 10.7270/Q22J6F7J
					More data for this Ligand-Target Pair
Histone deacetylase 9 (Homo sapiens (Human))	BDBM272085 ((S)-2-(4-(Difluoromethoxy)phenyl)-5-(3-fluoro-2- m...) Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cn(nc2C1)-c1ccc(OC(F)F)cc1)C(=O)NO |r| Show InChI InChI=1S/C21H18F3N3O3/c1-12-16(3-2-4-17(12)22)21(19(28)26-29)9-13-11-27(25-18(13)10-21)14-5-7-15(8-6-14)30-20(23)24/h2-8,11,20,29H,9-10H2,1H3,(H,26,28)/t21-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	147	n/a	n/a	n/a	n/a	n/a	n/a
CHDI Foundation, Inc. US Patent					Assay Description The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...				US Patent US10065948 (2018) BindingDB Entry DOI: 10.7270/Q2154K23
					More data for this Ligand-Target Pair