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BDBM272116 (S)-2-Cyclopropyl-6-(3-fluoro-2-methylphenyl)-N- hydroxy-6,7-dihydro-5H-cyclopenta[d]pyrimidine-6- carboxamide::US10065948, 52::US10457675, Example 52

SMILES: Cc1c(F)cccc1[C@@]1(Cc2cnc(nc2C1)C1CC1)C(=O)NO

InChI Key: InChIKey=RBXLMMUKOIVVKT-SFHVURJKSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 272116   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histone deacetylase 9


(Homo sapiens (Human))
BDBM272116
PNG
((S)-2-Cyclopropyl-6-(3-fluoro-2-methylphenyl)-N- h...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnc(nc2C1)C1CC1)C(=O)NO |r|
Show InChI InChI=1S/C18H18FN3O2/c1-10-13(3-2-4-14(10)19)18(17(23)22-24)7-12-9-20-16(11-5-6-11)21-15(12)8-18/h2-4,9,11,24H,5-8H2,1H3,(H,22,23)/t18-/m0/s1
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KEGG

UniProtKB/SwissProt

DrugBank
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PC cid
PC sid
UniChem
US Patent
n/an/a 160n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10457675 (2019)


BindingDB Entry DOI: 10.7270/Q22J6F7J
More data for this
Ligand-Target Pair
Histone deacetylase 9


(Homo sapiens (Human))
BDBM272116
PNG
((S)-2-Cyclopropyl-6-(3-fluoro-2-methylphenyl)-N- h...)
Show SMILES Cc1c(F)cccc1[C@@]1(Cc2cnc(nc2C1)C1CC1)C(=O)NO |r|
Show InChI InChI=1S/C18H18FN3O2/c1-10-13(3-2-4-14(10)19)18(17(23)22-24)7-12-9-20-16(11-5-6-11)21-15(12)8-18/h2-4,9,11,24H,5-8H2,1H3,(H,22,23)/t18-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 160n/an/an/an/an/an/a



CHDI Foundation, Inc.

US Patent


Assay Description
The potency of the compounds is quantified by measuring the Histone Deacetylase 9 (HDAC9) enzymatic activity using the fluorogenic substrate, Boc-Lys...


US Patent US10065948 (2018)


BindingDB Entry DOI: 10.7270/Q2154K23
More data for this
Ligand-Target Pair