BDBM272558 3-morpholino-1-pyrazolo[4,3-g]quinolin-7(8H)-one::US10065967, Example 24::US10759805, Ex 24::US9745307, Example 24

SMILES: O=c1ccc2cc3c(n[nH]c3cc2[nH]1)N1CCOCC1

InChI Key: InChIKey=MGLPAKZGLKAQTD-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 272558   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM272558 (3-morpholino-1-pyrazolo[4,3-g]quinolin-7(8H)-one |...) Show SMILES O=c1ccc2cc3c(n[nH]c3cc2[nH]1)N1CCOCC1 Show InChI InChI=1S/C14H14N4O2/c19-13-2-1-9-7-10-12(8-11(9)15-13)16-17-14(10)18-3-5-20-6-4-18/h1-2,7-8H,3-6H2,(H,15,19)(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Merck, Sharp & Dohme Corp. US Patent					Assay Description Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...				US Patent US10065967 (2018) BindingDB Entry DOI: 10.7270/Q2CF9S47
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM272558 (3-morpholino-1-pyrazolo[4,3-g]quinolin-7(8H)-one |...) Show SMILES O=c1ccc2cc3c(n[nH]c3cc2[nH]1)N1CCOCC1 Show InChI InChI=1S/C14H14N4O2/c19-13-2-1-9-7-10-12(8-11(9)15-13)16-17-14(10)18-3-5-20-6-4-18/h1-2,7-8H,3-6H2,(H,15,19)(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Human: Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound w...				US Patent US10759805 (2020)
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM272558 (3-morpholino-1-pyrazolo[4,3-g]quinolin-7(8H)-one |...) Show SMILES O=c1ccc2cc3c(n[nH]c3cc2[nH]1)N1CCOCC1 Show InChI InChI=1S/C14H14N4O2/c19-13-2-1-9-7-10-12(8-11(9)15-13)16-17-14(10)18-3-5-20-6-4-18/h1-2,7-8H,3-6H2,(H,15,19)(H,16,17)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...				US Patent US9745307 (2017) BindingDB Entry DOI: 10.7270/Q28G8NTK
					More data for this Ligand-Target Pair