BDBM274239 (R)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimethyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1-methyl-5,6-dihydropyrrolo[3,4-b]pyrrol-4(1H)-one::US9550796, Example 36

SMILES: Cc1nnc2c(C)cc(cn12)N1[C@@H](c2c(C1=O)c(cn2C)C1CC1)c1ccc(Cl)cc1

InChI Key: InChIKey=AVWFNEVSOVPOLY-OAQYLSRUSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 274239   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bromodomain-containing protein 4 (Homo sapiens (Human))	BDBM274239 ((R)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimeth...) Show SMILES Cc1nnc2c(C)cc(cn12)N1[C@@H](c2c(C1=O)c(cn2C)C1CC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C24H22ClN5O/c1-13-10-18(11-29-14(2)26-27-23(13)29)30-21(16-6-8-17(25)9-7-16)22-20(24(30)31)19(12-28(22)3)15-4-5-15/h6-12,15,21H,4-5H2,1-3H3/t21-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13	n/a	n/a	n/a	n/a	7.5	n/a
NOVARTIS AG US Patent					Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK
					More data for this Ligand-Target Pair
CREB-binding protein (Homo sapiens (Human))	BDBM274239 ((R)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimeth...) Show SMILES Cc1nnc2c(C)cc(cn12)N1[C@@H](c2c(C1=O)c(cn2C)C1CC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C24H22ClN5O/c1-13-10-18(11-29-14(2)26-27-23(13)29)30-21(16-6-8-17(25)9-7-16)22-20(24(30)31)19(12-28(22)3)15-4-5-15/h6-12,15,21H,4-5H2,1-3H3/t21-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	7.5	30
NOVARTIS AG US Patent					Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK
					More data for this Ligand-Target Pair
Bromodomain-containing protein 3 (Homo sapiens (Human))	BDBM274239 ((R)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimeth...) Show SMILES Cc1nnc2c(C)cc(cn12)N1[C@@H](c2c(C1=O)c(cn2C)C1CC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C24H22ClN5O/c1-13-10-18(11-29-14(2)26-27-23(13)29)30-21(16-6-8-17(25)9-7-16)22-20(24(30)31)19(12-28(22)3)15-4-5-15/h6-12,15,21H,4-5H2,1-3H3/t21-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	7.5	n/a
NOVARTIS AG US Patent					Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK
					More data for this Ligand-Target Pair
Bromodomain-containing protein 2 (Homo sapiens (Human))	BDBM274239 ((R)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimeth...) Show SMILES Cc1nnc2c(C)cc(cn12)N1[C@@H](c2c(C1=O)c(cn2C)C1CC1)c1ccc(Cl)cc1 |r| Show InChI InChI=1S/C24H22ClN5O/c1-13-10-18(11-29-14(2)26-27-23(13)29)30-21(16-6-8-17(25)9-7-16)22-20(24(30)31)19(12-28(22)3)15-4-5-15/h6-12,15,21H,4-5H2,1-3H3/t21-/m1/s1	PDB GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	7.5	n/a
NOVARTIS AG US Patent					Assay Description All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...				US Patent US9550796 (2017) BindingDB Entry DOI: 10.7270/Q2QN68SK
					More data for this Ligand-Target Pair